A comparison of electron-transfer rates of ferrocenoyl-linked DNA
A comparison of electron-transfer rates of ferrocenoyl-linked DNA
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DOI：
10.1021/ja034684x
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发表时间：
2003-07-23
影响因子：
15
通讯作者：
Kraatz, HB
中科院分区：
文献类型：
--
作者：
Long, YT;Li, CZ;Kraatz, HB
通过将二茂铁甲酰基（Fc）标记的和巯基标记的DNA连接到Au电极上，研究了两种构型的双链DNA的电子转移（ET）。第一种构型将Fc部分定位在与硫醇盐相同的链上，而第二种构型将Fc基团定位在互补链上。结构上的细微差异导致E0 '值（29 mV）和ET速率常数（25 vs 115 s-1）的差异。这些结果使人们对ds-DNA中的电子转移有了进一步的认识，并提出了几种电子转移模型。
Electron transfer (ET) through two configurations of double-stranded (ds)-DNA was investigated by the attachment of a ferrocenoyl (Fc)-labeled and thiol-labeled DNA to Au electrodes. The first configuration positions the Fc moiety on the same strand as the thiolate, whereas the second configuration positions the Fc group on the complementary strand. The subtle difference in structure leads to a difference inE0‘values (29 mV) and in ET rate constants (25 vs 115 s-1). The results have led to a further understanding of electron transfer in ds-DNA, and several models of ET are proposed.