CENTRAL ADMINISTRATION OF CORTICOTROPIN RELEASING-FACTOR INDUCES LONG-TERM SENSITIZATION TO D-AMPHETAMINE
CENTRAL ADMINISTRATION OF CORTICOTROPIN RELEASING-FACTOR INDUCES LONG-TERM SENSITIZATION TO D-AMPHETAMINE
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DOI：
10.1016/0006-8993(93)90982-s
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发表时间：
1993-03-26
期刊：
影响因子：
2.9
通讯作者：
LEMOAL, M
中科院分区：
文献类型：
--
作者：
CADOR, M;COLE, BJ;LEMOAL, M
促肾上腺皮质激素释放因子（CRF）已被证明启动神经内分泌和行为反应的压力。由于应激和苯丙胺（AMPH）表现出交叉敏化，我们研究了内源性CRF在D-AMPH行为敏化中的作用。为了评价CRF中枢作用的参与和对垂体-肾上腺皮质（PA）的兴奋作用，我们比较了反复侧脑室（i. c. v.）给药CRF（0，0.5，2.5 μ g/2穆尔），其具有中枢和神经内分泌的后果，与1周后重复皮下给药CRF（0，0.1，0.5，2.5 μ g/250穆尔），仅刺激PA轴的剂量，对AMPH诱导的运动激活的致敏性的发展。重复i.cv CRF的给药诱导了由0.75 mg/kg D-AMPH外周给药诱导的活动过度的持久增强，而在CRF的重复皮下给药后没有观察到对D-AMPH的致敏作用。这些结果支持CRF的中枢介导作用参与精神兴奋剂和应激的交叉致敏的假设。
Corticotropin releasing factor (CRF) has been shown to initiate neuroendocrine and behavioral responses to stress. As stress and amphetamine (AMPH) show cross-sensitization, we investigated the role of endogenous CRF in behavioral sensitization to D-AMPH. In order to evaluate the participation of the central action and the pituitary-adrenocortical (PA) stimulatory effect of CRF, we compared the effects of repeated intracerebroventricular (i.c.v.) administration of CRF (0, 0.5, 2.5 mug/2 mul), which have central and neuroendocrine consequences, with those of repeated subcutaneous administration of CRF (0, 0.1, 0.5, 2.5 mug/250 mul), doses which only stimulate the PA axis, on the development of sensitization to AMPH-induced motor activation administered 1 week later. Repeated i.cv. administration of CRF induced a long-lasting enhancement of the hyperactivity induced by 0.75 mg/kg peripheral administration of D-AMPH, whereas no sensitization to D-AMPH was observed following repeated subcutaneous administration of CRF. These results favor the hypothesis that a centrally mediated action of CRF is involved in the cross-sensitization of psychostimulants and stress.