Molecular imaging in cardiovascular disease: Which methods, which diseases?
Molecular imaging in cardiovascular disease: Which methods, which diseases?
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DOI：
10.1007/s12350-013-9785-0
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发表时间：
2013-12
影响因子：
2.4
通讯作者：
Sinusas, Albert
中科院分区：
文献类型：
--
作者：
Lindner, Jonathan R.;Sinusas, Albert
用于疾病相关分子变化的体内评估技术正在开发用于所有形式的非侵入性心血管成像。评估患者的组织分子或细胞表型的能力不仅有可能提高诊断能力，而且有可能通过在更适合治疗的早期阶段检测疾病或通过指导最合适的治疗来加强临床护理。这些新技术也可用于研究项目，以表征病理生理学，并作为疗效的替代终点。分子成像最常见的方法是创建新的靶向造影剂，这些造影剂的设计使得它们的动力学特性在疾病组织中不同。本综述的主要重点不是描述已开发的所有不同的分子成像方法，而是描述该领域的现状，并强调分子成像可能提供有意义的益处的一些临床和研究应用。具体目标领域包括评估动脉粥样硬化疾病、组织缺血以及心室和血管重塑。
Techniques for in vivo assessment of disease-related molecular changes are being developed for all forms of non-invasive cardiovascular imaging. The ability to evaluate tissue molecular or cellular phenotype in patients has the potential to not only improve diagnostic capabilities but to enhance clinical care either by detecting disease at an earlier stage when it is more amenable to therapy, or by guiding most appropriate therapies. These new techniques also can be used in research programs in order to characterize pathophysiology and as a surrogate endpoint for therapeutic efficacy. The most common approach for molecular imaging involves the creation of novel-targeted contrast agents that are designed so that their kinetic properties are different in disease tissues. The main focus of this review is not to describe all the different molecular imaging approaches that have been developed, but rather to describe the status of the field and highlight some of the clinical and research applications that molecular imaging will likely provide meaningful benefit. Specific target areas include assessment of atherosclerotic disease, tissue ischemia, and ventricular and vascular remodeling.
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