Lung Pathologic Findings in a Local Residential and Working Community Exposed to World Trade Center Dust, Gas, and Fumes
Lung Pathologic Findings in a Local Residential and Working Community Exposed to World Trade Center Dust, Gas, and Fumes
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DOI：
10.1097/jom.0b013e31822fff60
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发表时间：
2011-09-01
影响因子：
3.2
通讯作者：
Reibman, Joan
中科院分区：
文献类型：
--
作者：
Caplan-Shaw, Caralee E.;Yee, Herman;Reibman, Joan
目的：描述参加治疗计划的有症状的世贸中心暴露当地工人、居民和清理工人的病理结果。方法：12 名患者因疑似间质性肺疾病（第 1 组，n = 6）或肺功能检查异常（第 2 组，n = 6）而接受了外科肺活检。高分辨率计算机轴向断层扫描和病理结果被编码。采用能量色散 X 射线光谱仪进行扫描电子显微镜检查。结果：高分辨率计算机轴向断层扫描显示网状发现（第 1 组）或正常或气道相关发现（第 2 组）。肺功能测试主要是限制性的。可见间质纤维化、肺气肿改变和小气道异常。所有病例的巨噬细胞内都有不透明的双折射颗粒，并检查了颗粒中含有二氧化硅、硅酸铝、二氧化钛、滑石粉和金属。结论：在有症状的世贸中心暴露个体中，病理结果表明共同的暴露导致肺泡损失和对损伤的不同反应。
Objective: To describe pathologic findings in symptomatic World Trade Center-exposed local workers, residents, and cleanup workers enrolled in a treatment program. Methods: Twelve patients underwent surgical lung biopsy for suspected interstitial lung disease (group 1, n = 6) or abnormal pulmonary function tests (group 2, n = 6). High-resolution computed axial tomography and pathologic findings were coded. Scanning electron microscopy with energy-dispersive x-ray spectroscopy was performed. Results: High-resolution computed axial tomography showed reticular findings (group 1) or normal or airway-related findings (group 2). Pulmonary function tests were predominantly restrictive. Interstitial fibrosis, emphysematous change, and small airway abnormalities were seen. All cases had opaque and birefringent particles within macrophages, and examined particles contained silica, aluminum silicates, titanium dioxide, talc, and metals. Conclusions: In symptomatic World Trade Center-exposed individuals, pathologic findings suggest a common exposure resulting in alveolar loss and a diverse response to injury.