Ginger alleviates hyperglycemia-induced oxidative stress, inflammation and apoptosis and protects rats against diabetic nephropathy
Ginger alleviates hyperglycemia-induced oxidative stress, inflammation and apoptosis and protects rats against diabetic nephropathy
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DOI：
10.1016/j.biopha.2018.06.148
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发表时间：
2018-10-01
影响因子：
7.5
通讯作者：
Mahmoud, Ayman M.
中科院分区：
文献类型：
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作者：
Al Hroob, Amir M.;Abukhalil, Mohammad H.;Mahmoud, Ayman M.
氧化应激在糖尿病肾病（DN）的发生、发展中起重要作用。在这项研究中，生姜（Ephiber officinale）根茎提取物对高血糖诱导的氧化应激，炎症和细胞凋亡的潜在保护作用进行了研究。腹腔注射链脲佐菌素（STZ）建立实验性糖尿病大鼠模型。糖尿病大鼠经口给予400或800 mg/kg/天Z。药用植物提取物六周。糖尿病动物显示血糖水平和糖化血红蛋白（HbA 1c）升高，脂质谱改变。糖尿病大鼠血尿素氮、血肌酐、尿素和尿白蛋白水平显著升高。治疗Z。甘草可改善高血糖、高血脂及肾功能。此外，Z. officinale使糖尿病大鼠肾脏的组织学改变最小化。慢性高血糖导致大鼠肾脏中丙二醛、蛋白质羰基、促炎细胞因子、细胞色素c和半胱天冬酶-3显著增加。Z. officinale提取物显著减弱了糖尿病肾脏中的氧化应激、炎症和细胞凋亡，并增强了抗氧化防御。总之，本研究有力地表明，Z。药用根茎提取物通过改善氧化应激、炎症和细胞凋亡而对糖尿病诱导的肾损伤发挥保护作用。
Oxidative stress plays a major role in the development and progression of diabetic nephropathy (DN). In this study, the potential protective effect of ginger (Zingiber officinale) rhizome extract on hyperglycemia-induced oxidative stress, inflammation and apoptosis was investigated. An experimental diabetic rat model was induced by intraperitoneal injection of streptozotocin. Diabetic rats were treated orally with 400 or 800 mg/kg/day Z. officinale extract for six weeks. Diabetic animals exhibited elevated blood glucose levels and glycated hemoglobin (HbA1c) with altered lipid profile. Blood urea nitrogen, serum creatinine and urea, and urine albumin levels were significantly increased in diabetic rats. Treatment with Z. officinale ameliorated hyperglycemia, hyperlipidemia and kidney function. In addition, Z. officinale minimized the histological alterations in the kidney of diabetic rats. Chronic hyperglycemia resulted in a significant increase in malondialdehyde, protein carbonyl, pro-inflammatory cytokines, cytochrome c and caspase-3 in the kidney of rats. Z. officinale extract significantly attenuated oxidative stress, inflammation and apoptosis, and enhanced antioxidant defenses in the diabetic kidney. In conclusion, this study strongly suggests that Z. officinale rhizome extract exerts a protective role against diabetes-induced renal injury by ameliorating oxidative stress, inflammation and apoptosis.