Independent influences of body mass and gastric volumes on satiation in humans
Independent influences of body mass and gastric volumes on satiation in humans
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DOI：
10.1053/j.gastro.2003.11.007
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发表时间：
2004-02-01
期刊：
影响因子：
29.4
通讯作者：
Camilleri, M
中科院分区：
文献类型：
--
作者：
Delgado-Aros, S;Cremonini, F;Camilleri, M
背景和目的：我们评估了体重和胃容量（空腹和餐后）与饱腹感和餐后症状的关系。方法：健康肥胖和非肥胖受试者在最大饱腹感时测量热量摄入；餐后30分钟用视觉模拟量表测量餐后症状。使用 Technetium-99m 单光子发射计算机断层扫描成像测量禁食期间和 300 mL Ensure 后的胃体积。我们使用多元回归分析来评估变量之间的关联。结果：134 名参与者（81 名女性和 53 名男性）中，中位年龄为 26 岁（范围为 12-58 岁），中位体重指数为 24 kg/m(2)（范围为 17-48 kg/m(2)）。体重指数增加（而非身高）与延迟饱足感相关（P < 0.003，根据性别进行调整）。与正常体重个体相比，超重和肥胖受试者在最大饱腹感时平均多摄入 225 +/- 57 千卡热量 (945 +/- 239 M)。空腹胃容量增加与体重指数或身高无关，但与延迟饱足感显着相关（P = 0.001，根据体重指数和性别进行调整）。空腹胃容量增加 50 mL 时，最大饱腹感时摄入的热量增加 114 +/- 32 kcal (479 +/- 134 M)。体重指数增加与餐后 30 分钟饱腹感评分降低相关（P = 0.0012，根据性别和 Ensure 摄入量进行调整）。相比之下，餐后腹胀和疼痛的评分随着体重指数的增加而升高（均 P < 0.05，根据性别和 Ensure 摄入量进行调整）。结论：较大的体重指数和空腹胃容量与饱腹感降低相关。体重指数或身高的增加与胃容量的增加无关。
Background & Aims: We assessed the association of body mass and gastric volumes (fasting and postprandial) with satiation and postprandial symptoms. Methods: Healthy obese and nonobese subjects underwent measurement of caloric intake at maximum satiation; postprandial symptoms were measured with visual analogue scales 30 minutes after a meal. Gastric volume during fasting and after 300 mL of Ensure was measured with technetium-99m single-photon emission computed tomography imaging. We used multiple regression analysis to assess the associations among variables. Results: Among 134 participants (81 women and 53 men), the median age was 26 years (range, 12-58 years), and the median body mass index was 24 kg/m(2) (range, 17-48 kg/m(2)). Increased body mass index, but not height, was associated with delayed satiation (P < 0.003, adjusted for sex). Overweight and obese subjects ingested, on average, 225 +/- 57 more kilocalories (945 +/- 239 M) at maximum satiation compared with normal weight individuals. Increased fasting gastric volume was not associated with body mass index or height, but it was significantly associated with delayed satiation (P = 0.001, adjusted for body mass index and sex). An increase of 50 mL in the fasting gastric volume was associated with 114 +/- 32 kcal (479 +/- 134 M) more ingested at maximum satiation. Increased body mass index was associated with lower fullness scores 30 minutes after a meal (P = 0.0012, adjusted for sex and volume of Ensure ingested). In contrast, scores of postprandial bloating and pain were higher with increased body mass index (both P < 0.05, adjusted for sex and volume of Ensure ingested). Conclusions: Greater body mass index and fasting gastric volume are associated with reduced satiation. Increased body mass index or height was not associated with greater gastric volumes.