Cancer risks in Nordic immigrants and their offspring in Sweden
Cancer risks in Nordic immigrants and their offspring in Sweden
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DOI：
10.1016/s0959-8049(02)00496-3
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发表时间：
2002-12-01
影响因子：
8.4
通讯作者：
Li, X
中科院分区：
文献类型：
--
作者：
Hemminki, K;Li, X
已经进行了许多关于癌症的移民研究，但关于欧洲间移民的癌症发病率的数据很少。我们使用全国性的瑞典家庭癌症数据库来分析北欧移民及其在瑞典的后代的癌症风险。父母人口在20多岁时进入瑞典，他们在瑞典成为父母。芬兰人是最大的移民群体，包括大约183，000名父母和278，000名子女。我们计算了标准化发病率比（SIR）和90或95%的置信区间（CI）为26个癌症网站使用本地瑞典人作为参考。第一代移民的癌症发病率与原籍国相同，丹麦人与烟草有关的癌症、宫颈癌和睾丸癌以及芬兰人胃癌的系统免疫反应率都很高。只有少数癌症，如宫颈癌，在第二代中有所增加。在许多地方，特别是在芬兰人中间，在第一代就观察到了保护。在乳房、卵巢和膀胱这三个部位，甚至在后代中也发现了保护作用的可信证据，但在非遗传性父母的后代中没有得到加强，这与遗传效应不一致。对黑色素瘤的保护在同胞的后代中是最强的，但不能排除文化因素的影响。随着父母在20多岁时移民到瑞典，他们的癌症模式，包括习惯和生活方式，似乎在这个年龄之前就已经确定了，因为即使在老年人占主导地位的癌症中，瑞典人的差异也持续存在。移民人口似乎是研究癌症病因的有吸引力的主题，在那里的原因仍然知之甚少，如睾丸癌。(C)2002爱思唯尔科技有限公司版权所有。
Numerous migrant studies on cancer have been carried out, but little data are available on cancer incidence upon inter-European migration. We used the nationwide Swedish Family-Cancer Database to analyse cancer risk among Nordic immigrants and their offspring in Sweden. The parental population had entered Sweden in their 20s and they had become parents in Sweden. Finns were the largest immigrant group including approximately 183,000 parents and 278,000 offspring. We calculated the standardised incidence ratios (SIRs) and 90 or 95% confidence intervals (CIs) for 26 cancer sites using native Swedes as a reference. Cancers in the first generation immigrants followed the rates in the countries of origin, reaching high SIRs for tobacco-related, cervical and testicular cancer among Danes and for stomach cancer among Finns. Only a few cancers, such as cervical cancer was increased in the second generation. At many sites, particularly among the Finns, protection was observed in the first generation. At three sites, breast, ovary and urinary bladder, where plausible evidence for protection was found even among offspring, this was not reinforced among the offspring of compatriot parents, which is inconsistent with heritable effects. Protection against melanoma was strongest among the offspring of compatriots, but the contribution of cultural factors cannot be excluded. As the parents immigrated to Sweden in their 20s, their cancer pattern, including habits and life style, appeared to be set before that age because the differences to Swedes persisted even in cancers that predominate in old age. Immigrant populations would appear to be attractive subjects to study etiological factors of cancer at sites where causes remain poorly understood, such as testicular cancer. (C) 2002 Elsevier Science Ltd. All rights reserved.