COLLISIONAL ACTIVATION OF A SERIES OF HOMOCONJUGATED OCTADECADIENOIC ACIDS WITH FAST ATOM BOMBARDMENT AND TANDEM MASS-SPECTROMETRY
COLLISIONAL ACTIVATION OF A SERIES OF HOMOCONJUGATED OCTADECADIENOIC ACIDS WITH FAST ATOM BOMBARDMENT AND TANDEM MASS-SPECTROMETRY
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DOI：
10.1016/1044-0305(90)85055-q
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发表时间：
1990-03-01
影响因子：
3.2
通讯作者：
HOLMAN, RT
中科院分区：
文献类型：
--
作者：
CROCKETT, JS;GROSS, ML;HOLMAN, RT
长链脂肪酸离子的高能碰撞活化（CA）诱导发生在远离电荷位点的dcompositions。这些电荷远程碎片（CRF）已被证明提供了很多结构信息。本文用快原子轰击和串联质谱研究了12种共轭十八碳二烯酸的CRF。每种脂肪酸以羧酸根阴离子[M-H]-、二硫代羧酸根阴离子[M-H + 2Li]或钡代羧酸根阴离子[M-H + Ba]+的形式脱附，给出了三种电荷定位方式。一个特征图案产生的CRF的1，4-二烯官能团，这允许快速识别的官能团及其在链上的位置。对于不同的离子前体和双键的不同位置，观察到这种模式的微小变化。此外，不同类型的电荷近似反应，特别是脂肪酸羧酸盐的电荷近似反应，存在一些复杂性。
High-energy collisional activation (CA) of long-chain fatty acid ions induces dcompositions that occur remote from the charge site. These charage-remote fragmentations (CRFs) have been shown to provide much structural information. In this report, the CRF of a continuous series of 12 homoconjugated octadecdienoic acids was studied with fast atom bombardment and tandem mass spectrometry. Each fatty acid was desorbed as the carboxylate anion, [M - H]-, the dilithiated species, [M - H + 2Li], or the bariated species, [M - H + Ba]+, giving three ways of localizing the charge. A characteristic pattern is generated for CRF of the 1,4-diene functional group, and this allows for the rapid identification of the functional group and its location on the chain. Minor variations of this pattern are observed for the different ionic precursors and for different locations of the double bonds. Furthermore, there are a few complications from different types of charge-proximate reactions, especially of the fatty acid carboxylates.