Transformation of an antimicrobial peptide into a plasma membrane-permeable, mitochondria-targeted peptide via the substitution of lysine with arginine
Transformation of an antimicrobial peptide into a plasma membrane-permeable, mitochondria-targeted peptide via the substitution of lysine with arginine
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DOI：
10.1039/c2cc35872g
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发表时间：
2012-01-01
影响因子：
4.9
通讯作者：
Futaki, Shiroh
中科院分区：
文献类型：
--
作者：
Nakase, Ikuhiko;Okumura, Shinya;Futaki, Shiroh
抗菌肽(RLA)中的D-赖氨酸被D-精氨酸简单取代后，膜通透性显著提高，线粒体积累量增加。通过递送Bclx(L)BH4域的多肽，RLA在防止细胞凋亡方面的潜在应用也被证明。
Simple substitution of D-lysine with D-arginine in antimicrobial peptide (RLA) considerably improved its membrane permeability and increased mitochondrial accumulation. The potential use of RLA in preventing apoptotic cell death is also demonstrated through delivery of the Bcl-x(L) BH4 domain peptide.