THE STRUCTURAL BRAIN MUTANT VACUOLAR-MEDULLA OF DROSOPHILA-MELANOGASTER WITH SPECIFIC BEHAVIORAL DEFECTS AND CELL DEGENERATION IN THE ADULT
THE STRUCTURAL BRAIN MUTANT VACUOLAR-MEDULLA OF DROSOPHILA-MELANOGASTER WITH SPECIFIC BEHAVIORAL DEFECTS AND CELL DEGENERATION IN THE ADULT
复制标题
DOI：
10.3109/01677068609106845
复制
发表时间：
1986-05-01
影响因子：
1.9
通讯作者：
HEISENBERG, M
中科院分区：
文献类型：
--
作者：
COOMBE, PE;HEISENBERG, M
突变型Vam（延髓）在远端髓质中有空泡，这是由椎板和髓质中的年龄依赖性细胞变性引起的。板单极神经元L1和L2退化，但退化是否仅限于这些细胞是不确定的。羽化后1/2 h左右，细胞开始变性，空泡开始出现。这伴随着视网膜电图瞬变的消失和视动反应的丧失。Vam雄性或纯合子Vam雌性在羽化后一天或更晚，对水平或垂直运动没有可测量的视动反应，也没有着陆反应。然而，它们能够转向大于20 °的暗条纹。宽度。这表明运动依赖性视觉反应不是果蝇地标固定的先决条件。这种明显的缺陷表明，运动依赖性视觉功能的丧失是由于连接椎板和远端髓质的某些细胞类型的丧失。讨论了板层神经元在视动反应和注视行为中的作用。
The mutant Vam (Vacuolar medulla) has vacuoles in the distal medulla, caused by age-dependent cell degeneration in the lamina and the medulla. Lamina monopolar neurons L1 and L2 degenerate, but whether degeneration is confined only to these cells is uncertain. The cell degeneration commences at eclosion and the vacuoles begin appearing about 1/2 h after eclosion. This is accompanied by the disappearance of the electroretinogram transients and a loss of the optomotor response. Vam males or homozygous Vam females one day after eclosion or later, show no measurable optomotor response to horizontal or vertical movement and no landing response. However, they are able to turn towards dark stripes larger than 20.degree. in width. This indicates that motion-dependent visual responses are not a prerequisite for landmark fixation in Drosophila. The mutant''s apparent defects suggest that the loss of motion-dependent visual functions is due to the loss of certain cell types linking the lamina to the distal medulla. The role of lamina neurons in optomotor responses and fixation behavior is discussed.