Does standardized BMD still remove differences between Hologic and GE-Lunar state-of-the-art DXA systems?
Does standardized BMD still remove differences between Hologic and GE-Lunar state-of-the-art DXA systems?
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DOI：
10.1007/s00198-009-1062-3
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发表时间：
2010-07-01
影响因子：
4
通讯作者：
Shepherd, J.
中科院分区：
文献类型：
--
作者：
Fan, B.;Lu, Y.;Shepherd, J.
使用通用标准化方程导出的标准化骨矿物质密度（sBMD）值显示，在最先进的扇束双x射线吸收仪（DXA） Hologic和GE-Lunar系统中，髋部的等效值在1.0%之内，而脊柱的显着差异。两种系统间腰椎L1-L4和L2-L4 sBMD平均差异分别为0.042 g/cm(2)（4.1%）和0.035 g/cm(2)（3.2%）。本研究的目的是验证最先进的扇束DXA系统的1994铅笔束DXA“通用标准化方程”。在三个不同的临床中心使用Hologic Delphi和GE-Lunar Prodigy DXA系统对87名绝经后妇女的脊柱和双侧股骨进行扫描。使用Hologic Apex和GE-Lunar EnCore软件分析扫描结果。利用先前开发的方程将BMD结果转换为sBMD。采用线性回归分析来描述两种系统的骨密度结果之间的关系。使用Bland-Altman分析来评估测量方法的差异。Apex与Prodigy的sBMD值高度相关（r = 0.92 ~ 0.98）。腰椎L1-L4和L2-L4的sBMD值在Bland-Altman回归中具有显著的截距和斜率，平均差异分别为0.042 g/cm(2)（4.1%）和0.035 g/cm(2)（3.2%）。除左侧总sBMD差异为0.009 g/cm(2)（1.0%）外，两种系统间髋颈部总sBMD无显著截距和斜率。在两个系统上，髋关节的sBMD值在1.0%以内相等，而脊柱的sBMD值则有显著差异。来自不同制造商的汇总sBMD数据可能存在偏差，需要进一步研究以确定原因。
The standardized bone mineral density (sBMD) values, derived using universal standardized equations, were shown to be equivalent within 1.0% for hip but significantly different for spine for state-of-art fan-beam dual X-ray absorptiometry (DXA) Hologic and GE-Lunar systems. Spine L1-L4 and L2-L4 sBMD mean differences between the two systems were 0.042 g/cm(2) (4.1%) and 0.035 g/cm(2) (3.2%), respectively.The objective of this study is to validate the 1994 pencil-beam DXA "universal standardization equations" for state-of-the-art fan-beam DXA systems.The spine and bilateral femurs of 87 postmenopausal women were scanned on both Hologic Delphi and GE-Lunar Prodigy DXA systems at three different clinical centers. The scans were analyzed using Hologic Apex and GE-Lunar EnCore software. The BMD results were converted to sBMD using the equations previously developed. Linear regression analysis was used to describe the relationship of the two systems' BMD results. Bland-Altman analysis was used to assess the differences in measures.The Apex and Prodigy sBMD values were highly correlated (r ranged from 0.92 to 0.98). Spine L1-L4 and L2-L4 sBMD values had significant intercepts and slopes for Bland-Altman regression, with mean differences of 0.042 g/cm(2) (4.1%) and 0.035 g/cm(2) (3.2%), respectively. The total hip and neck sBMD showed no significant intercept and slope, except left total sBMD had a significant difference between the two systems of 0.009 g/cm(2) (1.0%).The sBMD values were shown to be equivalent within 1.0% for hip but were significantly different for spine on the two systems. Biases may persist in pooled sBMD data from different manufacturers, and further study is necessary to determine the cause.