EFFECT OF CHEMORECEPTOR STIMULATION AND INHIBITION ON TOTAL PULMONARY RESISTANCE IN HUMANS DURING NREM SLEEP
EFFECT OF CHEMORECEPTOR STIMULATION AND INHIBITION ON TOTAL PULMONARY RESISTANCE IN HUMANS DURING NREM SLEEP
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DOI：
10.1152/jappl.1994.76.4.1682
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发表时间：
1994-04-01
影响因子：
3.3
通讯作者：
DEMPSEY, JA
中科院分区：
文献类型：
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作者：
BADR, MS;SKATRUD, JB;DEMPSEY, JA
我们研究了化学感受器刺激和抑制对健康受试者在非快速眼动(NREM)睡眠中总肺阻力(RL)的影响。化学感受器刺激采用短暂等颅压低氧(n=8)。每分钟通风量增加到房间空气控制的150%。最大吸气流量时RL降至室内空气对照的66%。阻力压力-吸气流量曲线图显示，对于给定的吸气流量，阻力压力较低。化学感受器抑制是通过用100%O2(n=7)突然终止短暂的低二氧化碳缺氧来实现的。每分钟通风量减少到房间空气控制的63%。吸气高峰时或固定流量时计算的RL无显著变化，最低通气时的压力-流量曲线与室内空气控制相比无系统性变化。我们得出的结论是：1)低氧化学感受器刺激与RL降低和压力-流量关系增强有关，提示上呼吸道口径增加；2)在正常受试者的低机械驱动时期，上气道通畅不受影响；3)上气道扩张肌和胸泵肌肉选择性地与增加和降低的机械驱动相协调。
We investigated the effect of chemoreceptor stimulation and inhibition on total pulmonary resistance (RL) during non-rapid-eye-movement (NREM) sleep in healthy subjects. Chemoreceptor stimulation was accomplished with brief isocapnic hypoxia (n = 8). Minute ventilation increased to 150% of room air control. RL at peak inspiratory flow decreased to 66% of room air control. Resistive pressure-inspiratory flow plots demonstrated lower resistive pressures for a given inspiratory flow. Chemoreceptor inhibition was accomplished by abruptly terminating brief hypocapnic hypoxia with 100% O-2 (n = 7). Minute ventilation decreased to 63% of room air control. RL calculated at peak inspiratory or fixed flow did not change significantly, and pressure-flow plots at nadir ventilation showed no systematic change from room air control. We conclude that I) hypoxic chemoreceptor stimulation is associated with decreased RL and enhancement of pressure-flow relationships, suggesting increased upper airway caliber; 2) upper airway patency is not compromised during periods of low ventilatory drive in normal subjects; and 3) upper airway dilating muscles and thoracic pump muscles are optionally coordinated with increased and decreased ventilatory drive.