Sigma receptors as potential therapeutic targets for neuroprotection.
Sigma receptors as potential therapeutic targets for neuroprotection.
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DOI：
10.1016/j.ejphar.2014.09.022
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发表时间：
2014-11-15
影响因子：
5
通讯作者：
Matsumoto, Rae R.
中科院分区：
文献类型：
--
作者：
Nguyen, Linda;Kaushal, Nidhi;Robson, Matthew J.;Matsumoto, Rae R.
Sigma受体组成了一个独特的蛋白质家族，参与了许多中枢神经系统疾病的病理生理学和治疗，与它们在大脑和脊髓中的高水平表达一致。越来越多的证据表明，靶向sigma受体可能对许多神经退行性疾病特别有益，包括阿尔茨海默病、帕金森病、中风、甲基苯丙胺神经毒性、亨廷顿病、肌萎缩侧索硬化症和视网膜变性。从这一角度出发，对sigma受体进行了简要的概述，然后重点介绍了神经退行性变的常见机制，这些机制似乎可以通过sigma受体配体的调节来传递神经保护作用和/或恢复功能。在这里讨论的每个主要机制中，总结了西格玛配体的神经保护作用，并在已知的情况下，确定了涉及的特定西格玛受体亚型(S)。综上所述，这些文献表明，sigma受体可能通过神经元和神经胶质机制为对抗神经退行性疾病提供一个新的靶点。
Sigma receptors comprise a unique family of proteins that have been implicated in the pathophysiology and treatment of many central nervous system disorders, consistent with their high level of expression in the brain and spinal cord. Mounting evidence indicate that targeting sigma receptors may be particularly beneficial in a number of neurodegenerative conditions including Alzheimer's disease, Parkinson's disease, stroke, methamphetamine neurotoxicity, Huntington's disease, amyotrophic lateral sclerosis, and retinal degeneration. In this perspective, a brief overview is given on sigma receptors, followed by a focus on common mechanisms of neurodegeneration that appear amenable to modulation by sigma receptor ligands to convey neuroprotective effects and/or restorative functions. Within each of the major mechanisms discussed herein, the neuroprotective effects of sigma ligands are summarized, and when known, the specific sigma receptor subtype(s) involved are identified. Together, the literature suggests sigma receptors may provide a novel target for combatting neurodegenerative diseases through both neuronal and glial mechanisms.
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影响因子：
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