Effect of Statin Drugs on Thoracic Aortic Aneurysms
Effect of Statin Drugs on Thoracic Aortic Aneurysms
复制标题
DOI：
10.1016/j.amjcard.2013.05.081
复制
发表时间：
2013-10-15
影响因子：
2.8
通讯作者：
Elefteraides, John A.
中科院分区：
文献类型：
--
作者：
Stein, Louis H.;Berger, Jessica;Elefteraides, John A.
胸主动脉瘤的药物干预仍然缺乏特征。我们小组的一项初步研究结果表明，服用他汀类药物的胸主动脉瘤患者的预后有所改善。在本研究中，我们对耶鲁-纽黑文医院主动脉研究所数据库中的一个更大的患者队列进行了全面分析。共有1,560名患者符合入选标准。不良事件（即，死亡、夹层或破裂）和手术率进行比较。我们评价了主动脉的3个解剖组成部分：根部、升弓部、降部和胸腹主动脉瘤。他汀类药物组发生不良事件的比例较小：总体而言，7%对15%;升主动脉和主动脉弓，6%对15%;降主动脉和胸腹主动脉瘤，8%对20%。此外，他汀类药物组需要手术的患者比例较小：总体而言，48%对60%;升主动脉瘤和主动脉弓瘤，51%对62%;降主动脉瘤和胸腹主动脉瘤，36%对59%（p
Pharmacologic interventions for thoracic aneurysms remain poorly characterized. The results of a pilot study by our group suggested improved outcomes among patients with thoracic aortic aneurysm who were taking statins. In the present study, we undertook a comprehensive analysis of a larger cohort of patients from the Database of the Aortic Institute at Yale-New Haven Hospital. A total of 1,560 patients met the inclusion criteria. The adverse events (i.e., death, dissection, or rupture) and surgery rates for patients with (n = 369, 24%) and without (n = 1,191, 76%) statin therapy were compared. We evaluated 3 anatomic components of the aorta: root, ascending and arch, and descending and thoracoabdominal aortic aneurysms. A smaller proportion of the statin group had adverse events: overall, 7% versus 15%; ascending and arch, 6% versus 15%; and descending and thoracoabdominal aortic aneurysms, 8% versus 20%. Also, a smaller proportion of statin patients required surgery: overall, 48% versus 60%; ascending and arch, 51% versus 62%; and descending and thoracoabdominal aortic aneurysms, 36% versus 59% (p