A comparison of the effects of angiotensin II and heptapeptide on smooth muscle (vascular and uterine).
A comparison of the effects of angiotensin II and heptapeptide on smooth muscle (vascular and uterine).
复制标题
血管紧张素 II 和七肽对平滑肌（血管和子宫）的影响的比较。
DOI：
10.1016/0014-2999(76)90117-5
复制
发表时间：
1976
影响因子：
5
通讯作者：
P. Khairallah
中科院分区：
文献类型：
--
作者：
A. Moore;M. Hall;P. Khairallah
在兔离体主动脉上，获得了血管紧张素 II 和七肽（[des-Asp1]-血管紧张素 II）的剂量依赖性收缩。曲线是平行的，并且达到了相同的最高水平。在大鼠离体子宫上，血管紧张素 II 和七肽表现出非平行的剂量反应曲线。血管紧张素类似物拮抗剂和交叉快速耐受实验获得的结果表明，七肽和血管紧张素II优先作用于子宫中不同的受体群体。吲哚美辛对大鼠离体主动脉快速耐受恢复的作用差异表明，血管紧张素 II 和七肽诱导这两种肽诱导快速耐受的机制可能不同。 SQ 20881 是一种血管紧张素转换酶抑制剂，完全抑制子宫对十肽和九肽的反应，同时略微增强对血管紧张素 II 和七肽的反应。吲哚美辛对子宫对血管紧张素 II 或七肽的反应没有显着影响。
On the rabbit isolated aorta, dose-dependent contractions to both angiotensin II and heptapeptide ([des-Asp1]-angiotensin II) were obtained. The curves were parallel, and reached the same maximum level. On the rat isolated uterus, angiotensin II and the heptapeptide displayed non-parallel dose—response curves. Results obtained with angiotensin-analog antagonists and cross-tachyphylaxis experiments suggest that the heptapeptide and angiotensin II act, preferentially, on different populations of receptors in the uterus. The difference in action of indomethacin on recovery from tachyphylaxis to angiotensin II and heptapeptide on rat isolated aorta suggests that the mechanism of induction of tachyphylaxis by these two peptides may differ. SQ 20881, the angiotensin converting enzyme inhibitor, totally inhibites uterine responses to both decapeptide and nonapeptide, while slightly potentiating those to angiotensin II and heptapeptide. Indomethacin had no significant effect on uterine responses to either angiotensin II or the heptapeptide.