Sympathetic responses of the heart and adrenal medulla in developing Dahl hypertensive rats.
Sympathetic responses of the heart and adrenal medulla in developing Dahl hypertensive rats.
复制标题
发育中的达尔高血压大鼠心脏和肾上腺髓质的交感反应。
DOI：
10.1016/0031-9384(87)90258-7
复制
发表时间：
1987
影响因子：
2.9
通讯作者：
McCarty,R
中科院分区：
文献类型：
--
作者：
Murphy,CA;Cierpial,MA;Borom,AH;McCarty,R
在近交系Dahl盐敏感（S/JR）和耐盐（R/JR）大鼠中，通过评估心脏和肾上腺髓质对2、4、8、12和16日龄胰岛素诱导的低血糖的反应，检查交感神经系统的功能发育。心脏鸟氨酸脱羧酶（ODC）活性和肾上腺儿茶酚胺含量测定后3小时，无论是生理盐水或胰岛素的两个菌株的幼崽。胰岛素诱导的低血糖引起的中枢介导的交感神经流出增加伴随着心脏ODC活性的诱导和肾上腺素（EPI）的耗竭。R/JR和S/JR品系之间在心脏ODC活性或肾上腺素方面总体上无显著差异。这对于从注射生理盐水的幼仔获得的基础值以及从注射胰岛素的幼仔获得的测量值是真实的。两种品系的幼鼠早在2日龄时就存在心脏的功能性神经支配，而在肾上腺髓质中，直到8日龄才检测到对刺激的显著反应。虽然盐敏感动物的高血压易感性可能与交感神经张力增加有关，但本研究结果表明，S/JR大鼠在断奶前没有加速发育或交感神经输入对心脏或肾上腺髓质的高反应性。
Functional development of the sympathetic nervous system was examined in inbred Dahl salt-sensitive (S/JR) and salt-resistant (R/JR) rats by assessing cardiac and adrenal medullary responses to insulin-induced hypoglycemia at 2, 4, 8, 12, and 16 days of age. Heart ornithine decarboxylase (ODC) activity and adrenal catecholamine content were measured in pups of the two strains 3 hours after administration of either saline or insulin. The centrally mediated increase in sympathetic outflow caused by insulin-induced hypoglycemia was attended by induction of heart ODC activity and depletion of adrenal epinephrine (EPI). No significant differences were found overall between R/JR and S/JR strains with regard to either heart ODC activity or adrenal epinephrine. This was true for basal values obtained from saline-injected pups as well as for measures from insulin-injected pups. Functional innervation of the heart was present in pups of both strains as early as 2 days of age, while in the adrenal medulla a significant response to stimulation was not detected until 8 days of age. While the susceptibility for hypertension in the salt-sensitive animals may well be linked to increased sympathetic tone, the present findings indicate that S/JR rats do not have an accelerated development or a hyperresponsiveness of sympathetic input to either the heart or the adrenal medulla during the pre-weanling period.