Lack of effect of psychosocial stress on maternal corticotropin-releasing factor and catecholamine levels at 28 weeks' gestation
Lack of effect of psychosocial stress on maternal corticotropin-releasing factor and catecholamine levels at 28 weeks' gestation
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DOI：
10.1016/s1071-5576(01)00095-8
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发表时间：
2001-03-01
期刊：
影响因子：
--
通讯作者：
Berkowitz, GS
中科院分区：
文献类型：
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作者：
Petraglia, F;Hatch, MC;Berkowitz, GS
目的：促肾上腺皮质激素释放因子(CRF)和儿茶酚胺是应激反应过程中被激活的主要激素之一。在孕妇中，血清CRF和儿茶酚胺水平在分娩和早产期间会增加。本研究的目的是评估心理社会应激措施是否与健康中期妊娠妇女的血清CRF或尿儿茶酚胺[即肾上腺素、去甲肾上腺素(NE)、多巴胺(DA)]水平相关。工作条件问卷和精神流行病学研究访谈分别用于测量工作压力和一般生活压力。在进行心理社会评估时，采集妊娠28周时的尿样和血样。尿液中肾上腺素、去甲肾上腺素和多巴胺的测定采用基于安培检测器的高灵敏度方法。采用放射免疫法测定血清CRF和皮质醇水平。结果：心理测验高、低分患者血清CRF和皮质醇水平无明显差异，CRF和皮质醇水平之间无相关性。其中一项工作压力测量指标，工作纬度低，与下午和晚上NE和DA水平的轻度升高显著相关(P
OBJECTIVE: Corticotropin-releasing factor (CRF) and catecholamines are among the major hormones activated during the adaptive response to stressful stimuli. In pregnant women, serum CRF and catecholamines levels increase during labor and preterm delivery. The aim of the present study was to evaluate whether psychosocial stress measures are correlated with serum CRF or urinary catecholamine [ie, epinephrine, norepinephrine (NE), dopamine (DA)] levels in healthy midtrimester pregnant women.METHODS: A large group of white pregnant women (n = 382) participated in the present study. The Work Conditions Questionnaire and the Psychiatric Epidemiology Research Interview were administered to measure job stress and general life stress, respectively. Urine and blood specimens were collected at 28 weeks of gestation at the time of psychosocial evaluation. Epinephrine, NE, and DA were quantified in the urine by a highly sensitive method based on an amperometric detector. Serum CRF and cortisol levels were measured in blood specimens by using specific radioimmunoassays.RESULTS: Serum CRF and cortisol levels did not vary between patients with high and low scores on psychological tests, and no correlation was found between CRF and cortisol levels. One job stress measure, low job latitude, was significantly associated with a mild increase in NE and DA levels in the afternoon and night (P