Dietary conjugated linoleic acid reduces plasma lipoproteins and early aortic atherosclerosis in hypercholesterolemic hamsters.
Dietary conjugated linoleic acid reduces plasma lipoproteins and early aortic atherosclerosis in hypercholesterolemic hamsters.
复制标题
DOI：
--
复制
发表时间：
1997
期刊：
影响因子：
--
通讯作者：
R. Nicolosi;E. Rogers;D. Kritchevsky;J. Scimeca;P. Huth
中科院分区：
文献类型：
--
作者：
R. Nicolosi;E. Rogers;D. Kritchevsky;J. Scimeca;P. Huth
共轭亚油酸是一个集合术语，用于指定亚油酸的位置和几何异构体的混合物，其中双键是共轭的。与亚油酸不同，关于饮食中共轭亚油酸对血浆脂蛋白和主动脉粥样硬化的影响的信息很少。因此，将50只仓鼠分为5组，每组10只，分别饲喂0（对照）、0.06（低）、0.11（中）和1.1（高）en%共轭亚油酸或1.1 en%亚油酸。在第4、8和11周采集血样，用于血浆脂质分析，并在处死时进行血浆生育酚测定。与对照组相比，饲喂含共轭亚油酸饲料的动物的血浆总胆固醇、非高密度脂蛋白胆固醇（极低密度脂蛋白和低密度脂蛋白组合）和甘油三酯水平显著降低，对高密度脂蛋白胆固醇无影响。与对照组相比，亚油酸喂养动物的血浆总胆固醇、非高密度脂蛋白胆固醇和甘油三酯也有所降低，但仅后者具有统计学显著性。与对照组相比，低、中和高共轭亚油酸和亚油酸组的血浆池测定的血浆生育酚/总胆固醇比值分别增加了48%、48%、86%和29%，表明至少共轭亚油酸处理具有生育酚节约效应。动脉粥样硬化的形态学分析显示，与对照组相比，共轭亚油酸和亚油酸喂养的仓鼠的早期动脉粥样硬化较少。
Conjugated linoleic acid is a collective term used to designate a mixture of positional and geometric isomers of linoleic acid in which the double bonds are conjugated. Unlike linoleic acid, there is a paucity of information regarding the effect of dietary conjugated linoleic acid on plasma lipoproteins and aortic atherosclerosis. Therefore, fifty hamsters were divided into five groups of ten and fed 0 (Control), 0.06 (LOW), 0.11 (MEDIUM), and 1.1 (HIGH) en% conjugated linoleic acid or 1.1 en% linoleic acid. Blood samples were taken at 4, 8 and 11 weeks for plasma lipid analyses and for plasma tocopherol assay at sacrifice. Animals fed the conjugated linoleic acid-containing diets collectively had significantly reduced levels of plasma total cholesterol, non-high density lipoprotein cholesterol, (combined very low and low density lipoprotein) and triglycerides with no effect on high density lipoprotein cholesterol, as compared to CONTROLs. Linoleic acid-fed animals relative to CONTROLs also had reduced plasma total cholesterol, non-high density lipoprotein cholesterol and triglycerides, but only the latter was statistically significant. Compared to the CONTROL group, plasma tocopherol/total cholesterol ratios determined from plasma pools for the LOW, MEDIUM and HIGH conjugated linoleic acid and linoleic acid groups were increased by 48%, 48%, 86% and 29%, respectively, suggesting a tocopherol-sparing effect, at least for the conjugated linoleic acid treatment. Morphometric analysis of aortas revealed less early atherosclerosis in the conjugated linoleic acid and linoleic acid-fed hamsters compared to the CONTROL group.