Osteoactivin attenuates skeletal muscle fibrosis after distraction osteogenesis by promoting extracellular matrix degradation/remodeling.
Osteoactivin attenuates skeletal muscle fibrosis after distraction osteogenesis by promoting extracellular matrix degradation/remodeling.
复制标题
骨激活素通过促进细胞外基质降解/重塑来减轻牵张成骨后的骨骼肌纤维化。
DOI：
10.1097/bpb.0000000000000117
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发表时间：
2015
影响因子：
1.1
通讯作者：
Sairyo K.
中科院分区：
文献类型：
--
作者：
Tonogai I;Takahashi M;Yukata K;Sato R;Nikawa T;Yasui N;Sairyo K.
本研究的目的是确定骨激活素是否能减轻牵张成骨引起的骨骼肌纤维化。对野生型和骨活化素转基因(OA-TG)小鼠进行胫骨截骨，牵张2周。分析踝足底屈曲扭矩和腓肠肌的变化。术后8周，OA-TG组的胶原组织数量、面积和被动扭矩均较术前减少。在OA-TG组，基质金属蛋白酶-3和基质金属蛋白酶-9的转录水平上调，基质金属蛋白酶-3和基质金属蛋白酶-9的蛋白表达增加。骨激活素介导的MMPs的增加可能会减轻骨骼肌纤维化。
The aim of this study was to determine whether osteoactivin attenuated skeletal muscle fibrosis caused by distraction osteogenesis. Tibial osteotomies were performed on wild-type and osteoactivin-transgenic (OA-Tg) mice, and tibiae were distracted for 2 weeks. Ankle plantar flexion torque and the gastrocnemius muscles were analyzed. The amount and area of collagenous tissue and the passive torque were reduced in the OA-Tg group at 8 weeks after osteotomy. Transcript levels of matrix metalloprotease (mmp)-3 and MMP-9 were upregulated, and MMP-3 and MMP-9 proteins were increased in the OA-Tg group. Osteoactivin-mediated increase in MMPs may attenuate skeletal muscle fibrosis.