Fat distribution and storage: how much, where, and how?
Fat distribution and storage: how much, where, and how?
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DOI：
10.1530/eje-07-0125
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发表时间：
2007-08-01
影响因子：
5.8
通讯作者：
Weiss, Ram
中科院分区：
文献类型：
--
作者：
Weiss, Ram
肥胖并不一定意味着疾病，同样肥胖的人可能表现出与肥胖相关的发病率，或者看起来健康状况相当好。最近的研究表明，脂质分配模式是代谢特征的主要决定因素，而不仅仅是肥胖本身。脂质沉积在内脏室和胰岛素敏感组织的潜在机制和临床相关性进行了描述。增加的细胞内脂质沉积损害胰岛素信号转导途径，并与胰岛素抵抗有关。肝脂质沉积的增加同样与胰岛素抵抗综合征的大多数成分相关。增加循环脂肪酸在胰岛素抵抗和特定肥胖模式的典型促炎环境条件下的作用。深入了解细胞内脂质储存的模式，以及它们与胰岛素敏感性变化和体重减轻的关系。
Obesity does not necessarily imply disease and similarly obese individuals may manifest obesity-related morbidity or seemingly be in reasonably good health. Recent studies have shown that patterns of lipid partitioning are a major determinant of the metabolic profile and not just obesity per se. The underlying mechanisms and clinical relevance of lipid deposition in the visceral compartment and in insulin-sensitive tissues are described. Increased intramyocellular lipid deposition impairs the insulin signal transduction pathway and is associated with insulin resistance. Increased hepatic lipid deposition is similarly associated with the majority of the components of the insulin resistance syndrome. The roles of increased circulating fatty acids in conditions of insulin resistance and the typical pro-inflammatory milieu of specific obesity patterns are provided. Insights into the patterns of lipid storage within the cell are provided along with their relation to changes in insulin sensitivity and weight loss.