Adverse Infant Outcomes Associated With First-Trimester Vaginal Bleeding
Adverse Infant Outcomes Associated With First-Trimester Vaginal Bleeding
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DOI：
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发表时间：
1991-07
影响因子：
7.2
通讯作者：
Michelle A Williams;R. Mittendorf;E. Lieberman;R. Monson
中科院分区：
文献类型：
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作者：
Michelle A Williams;R. Mittendorf;E. Lieberman;R. Monson
我们评估了11,444名非糖尿病妇女的妊娠早期阴道出血与单胎婴儿结局之间的关系。低出生体重（LBW）、妊娠期缩短、足月LBW和新生儿死亡在报告妊娠早期出血的妇女中比在从未出血的妇女中更常见。在调整混杂因素后，这些关系仍然具有统计学意义。妊娠早期有阴道出血的妇女（N=1174）与没有出血的妇女相比，早产的风险增加了一倍（调整后的风险比=2.0；95%可信区间为1.6-2.5）。妊娠早期出血与分娩足月LBW婴儿的1.6倍风险相关（95%可信区间1.3-2.0）。这些结果表明，妊娠早期阴道出血是不良婴儿结局的重要相关因素。
We assessed the association between first-trimester vaginal bleeding and singleton infant outcomes in a hospital-based population of 11,444 nondiabetic women. Low birth weight (LBW), shortened gestation, LBW at term, and neonatal death occurred more often in women reporting first-trimester bleeding than in those who never bled. These relationships remained statistically significant after adjusting for confounding factors. Women who experienced vaginal bleeding limited to the first trimester (N=1174) had double the risk of delivering a preterm infant compared with those experiencing no bleeding (adjusted risk ratio=2.0; 95% confidence interval 1.6-2.5). Bleeding limited to the first trimester was associated with a 1.6-fold risk of delivery of a term LBW infant (95% confidence interval 1.3-2.0). These results suggest that first-trimester vaginal bleeding is an important correlate of adverse infant outcomes.