Moisture barrier films for herbal medicines fabricated by electrostatic dry coating with ultrafine powders
Moisture barrier films for herbal medicines fabricated by electrostatic dry coating with ultrafine powders
复制标题
采用超细粉末静电干法涂覆制备的草药防潮膜
DOI：
10.1016/j.powtec.2020.03.023
复制
发表时间：
2020-04-15
影响因子：
5.2
通讯作者：
Zhu, Jesse
中科院分区：
文献类型：
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作者：
Yang, Qingliang;Yuan, Feng;Zhu, Jesse
阻隔薄膜包衣是保护固体剂型免受潮湿影响的最合适和最广泛使用的方法，特别是对于包括草药在内的水敏感药物。本研究旨在利用羟丙基纤维素超细粉末，采用静电沉积工艺制备典型草药的阻隔膜，以达到防潮的功能。通过添加合适的纳米添加剂，超细粉末的流动性得到显着改善。涂料配方中使用的增塑剂对薄膜的水蒸气透过性有显着影响。此外，静电沉积效率受静电枪充电电压和增塑剂比例的显着影响。就表面形态和吸湿性而言，固化时间和温度被确定为屏障涂层的两个关键参数。所有结果表明静电沉积工艺能够生产高效的草药阻隔膜。 (C) 2020 Elsevier B.V. 保留所有权利。
Barrier film coating is the most appropriate and widely used approach to protect solid dosages from moisture, particularly for water-sensitive drugs including herbal medicines. This study aims to produce the barrier film of a typical herbal medicine by applying an electrostatic deposition process with ultrafine powders of hydroxypropyl cellulose so as to achieve the functionality of moisture protection. The flowability of the ultrafine powders was significantly improved by adding suitable nano additives. The applied plasticizer in the coating formulation had a significant effect on the water vapor permeability of the film. Also, the electrostatic deposition efficiency were significantly affected by the charging voltage of the electrostatic gun and the plasticizer ratio. Curing time and temperature were identified as two critical parameters for barrier coating in terms of surface morphology and hygroscopicity. All the results suggested that the electrostatic deposition process is capable to produce efficient barrier film for herbal medicines. (C) 2020 Elsevier B.V. All rights reserved.