Molecular mechanisms underlying the anticancer property of Dendrobium in various systems of the human body: A review.
Molecular mechanisms underlying the anticancer property of Dendrobium in various systems of the human body: A review.
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DOI：
10.1016/j.biopha.2023.115223
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发表时间：
2023-07
期刊：
影响因子：
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通讯作者：
Wen-Jian Yang;Dengwang Chen;Qinglu Ji;Jishan Zheng;Yunyan Ma;H. Sun;Qian Zhang;Jidong Zhang-Jidong-Zha
中科院分区：
文献类型：
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作者：
Wen-Jian Yang;Dengwang Chen;Qinglu Ji;Jishan Zheng;Yunyan Ma;H. Sun;Qian Zhang;Jidong Zhang-Jidong-Zha
石斛属兰科植物，是我国常用的名贵中药材。它具有抗肿瘤、降血糖等药理活性，主要成分为生物碱、多糖、萜类等。近年来，石斛碱在抗肿瘤治疗中的临床应用研究日益受到重视。越来越多的证据表明，石斛属植物的活性成分对癌细胞的活力具有显著的抑制作用，这表明石斛属植物在治疗和预防癌症发展方面具有显著的抗癌作用，抑制潜在的分子机制，包括抑制癌细胞的生长和增殖，上皮-间质转化（EMT），诱导凋亡，肿瘤血管生成和增强顺铂（DDP）诱导的细胞凋亡。本文就石斛碱在肿瘤治疗中的应用及其分子机制的研究进展作一综述。本文综述了石斛有效成分在人体各系统肿瘤治疗中的积极作用、对肿瘤生存和肿瘤微环境的抑制作用及其可能的作用机制。本文还对石斛碱在肿瘤治疗中的应用前景进行了展望，以促进石斛碱在肿瘤治疗中的进一步研究和临床应用。
Dendrobium,which belongs to the family of Orchidaceae, is a highly valuable traditional Chinese medicine commonly used in China. It exerts pharmacological activities such as antitumor and hypoglycemia effects, and its main components are alkaloids, polysaccharides, and terpenoids, among others. In recent years, research on the clinical application ofDendrobiumin antitumor therapy has gained increasing attention. Accumulating evidence suggests that the active components ofDendrobiumpossess significant inhibitory effects on the viability of cancer cells as evident from invivoand invitroexperiments, which indicates thatDendrobiumexerts significant anticancer effect in treating and preventing cancer development, inhibiting the underlying potential molecular mechanisms, including suppression of cancer cell growth and proliferation, epithelial-mesenchymal transition (EMT), apoptosis induction, tumor angiogenesis, and reinforcement of cisplatin (DDP) -induced apoptosis. We herein present a review that summarizes the research progress of the application ofDendrobiumin cancer therapy and its molecular mechanisms. This review describes the positive aspects of the active ingredients ofDendrobiumin the treatment of cancers in various systems of the human body, their inhibitory effects on tumor survival and tumor microenvironment, and their potential mechanisms. Additionally, this review proposes future application prospects ofDendrobiumin cancer therapy to promote further research and future extensive clinical applications ofDendrobiumin cancer therapy.