RatCAP: Miniaturized head-mounted PET for conscious rodent brain imaging
RatCAP: Miniaturized head-mounted PET for conscious rodent brain imaging
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DOI：
10.1109/tns.2004.835740
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发表时间：
2004-10-01
影响因子：
1.8
通讯作者：
Fontaine, R
中科院分区：
文献类型：
--
作者：
Vaska, P;Woody, CL;Fontaine, R
麻醉是目前所需要的正电子发射断层扫描（PET）研究的动物大脑，以消除运动伪影。然而，麻醉深刻地影响动物的神经系统状态，使PET数据的解释复杂化。此外，它排除了使用PET来研究正常行为期间的大脑。大鼠清醒动物PET断层扫描仪（RatCAP）旨在消除大鼠大脑研究中的麻醉需求。它是一种小型化的全环PET扫描仪，直接连接到头部，几乎对整个大脑进行成像。RatCAP利用2 mm x 2 mm LSO晶体阵列耦合到匹配的雪崩光电二极管阵列，这些阵列又由完全定制的集成电路读出。主要的挑战已经得到解决，考虑到除了小动物PET的通常要求，如在视差的存在下的高空间分辨率的尺寸，重量和热生成的物理约束。已经建造了一个部分原型，并完成了初步的测量和优化。还进行了逼真的蒙特卡罗模拟，以优化系统性能，预计将与现有的microPET系统竞争。
Anesthesia is currently required for positron emission tomography (PET) studies of the animal brain in order to eliminate motion artifacts. However, anesthesia profoundly affects the neurological state of the animal, complicating the interpretation of PET data. Furthermore, it precludes the use of PET to study the brain during normal behavior. The rat conscious animal PET tomograph (RatCAP) is designed to eliminate the need for anesthesia in rat brain studies. It is a miniaturized full-ring PET scanner that is attached directly to the head, imaging nearly the entire brain. RatCAP utilizes arrays of 2 mm x 2 mm LSO crystals coupled to matching avalanche photodiode arrays, which are in turn read out by full custom integrated circuits. Principal challenges have been addressed considering the physical constraints on size, weight, and heat generation in addition to the usual requirements of small-animal PET, such as high spatial resolution in the presence of parallax error. A partial prototype has been constructed and preliminary measurements and optimization completed. Realistic Monte Carlo simulations have also been carried out to optimize system performance, which is predicted to be competitive with existing microPET systems.