Dermoscopy of solitary angiokeratomas - A morphological study
Dermoscopy of solitary angiokeratomas - A morphological study
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DOI：
10.1001/archderm.143.3.318
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发表时间：
2007-03-01
影响因子：
--
通讯作者：
Malvehy, Josep
中科院分区：
文献类型：
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作者：
Zaballos, Pedro;Daufi, Cinta;Malvehy, Josep
目的：描述与孤立性血管角化瘤相关的皮肤镜结构和模式，并确定这些皮肤镜特征的敏感性、特异度、阳性预测值、阴性预测值和重复性。设计：多中心回顾研究。地点：西班牙、意大利、阿根廷、纽约和奥地利的大学医院。患者：从8家医院的实验室连续收集256例患者，32例孤立性血管角化瘤、黑色素细胞痣、斯匹兹里德痣、恶性黑色素瘤、色素基底细胞癌、皮肤纤维瘤、脂溢性角化病和其他血管病变(19例血管瘤、7例化脓性瘤、3例蜘蛛状新生血管、2例淋巴管瘤和1例静脉湖)。主要观察指标：计算与孤立性血管角化瘤相关的不同皮肤镜特征的频率、敏感度、特异度、阳性预测值、阴性预测值、观察者间的一致性和观察者间的一致性，并用CHI(2)或Fisher精确检验评估差异。结果：至少50%的孤立性血管角化瘤有6种皮肤镜结构：暗腔(94%)、白色面纱(91%)、红斑(69%)、外周红斑(53%)、红色腔隙(53%)和出血性结痂(53%)。黑色陷窝的敏感度为93.8%，特异度为99.1%(P
Objectives: To describe the dermoscopic structures and patterns associated with solitary angiokeratomas and to determine the sensitivity, specificity, positive predictive value, negative predictive value, and reproducibility of these dermoscopic features.Design: Multicenter retrospective study.Setting: University hospitals in Spain, Italy, Argentina, New York City, and Austria.Patients: There were 256 patients total, and 32 specimens each of solitary angiokeratomas, melanocytic nevi, Spitz-Reed nevi, malignant melanomas, pigmented basal cell carcinomas, dermatofibromas, seborrheic keratoses, and other vascular lesions (19 angiomas, 7 pyogenic granulomas, 3 spider nevi, 2 lymphangiomas, and 1 venous lake) were consecutively collected from the laboratories of 8 hospitals. Diagnoses of all patients' lesions were confirmed histopathologically.Intervention: Dermoscopic examination.Main Outcome Measures: The frequency, sensitivity, specificity, positive predictive value, negative predictive value, intraobserver agreement, and interobserver agreement of the different dermoscopic features associated with solitary angiokeratomas were calculated, and the differences were evaluated using the chi(2) or Fisher exact test.Results: Six dermoscopic structures were evident in at least 50% of the solitary angiokeratomas: dark lacunae (94%), whitish veil (91%), erythema (69%), peripheral erythema (53%), red lacunae (53%), and hemorrhagic crusts (53%). Dark lacunae exhibited a sensitivity of 93.8% and a specificity of 99.1% (P