Melanoma treatment in review.
Melanoma treatment in review.
复制标题
综述中的黑色素瘤治疗。
DOI：
10.2147/itt.s134842
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发表时间：
2018
影响因子：
7.2
通讯作者：
Pópulo H
中科院分区：
文献类型：
--
作者：
Domingues B;Lopes JM;Soares P;Pópulo H
黑色素瘤是最具侵略性和最致命的皮肤癌。目前的治疗方法包括手术切除、化学疗法、光动力疗法、免疫疗法、生物化学疗法和靶向疗法。治疗策略可以包括单一药物或联合治疗，这取决于患者的健康状况、阶段和肿瘤的位置。这些治疗的效率可能会降低，由于不同的抗性机制的发展。新的治疗靶点已经从黑素细胞的遗传特征的研究和从参与恶性转化的发病机制的分子因子的鉴定中出现。在这篇综述中，我们的目的是调查已批准和正在评估的黑色素瘤治疗和相关研究的黑色素瘤发生的分子机制。
Melanoma represents the most aggressive and the deadliest form of skin cancer. Current therapeutic approaches include surgical resection, chemotherapy, photodynamic therapy, immunotherapy, biochemotherapy, and targeted therapy. The therapeutic strategy can include single agents or combined therapies, depending on the patient’s health, stage, and location of the tumor. The efficiency of these treatments can be decreased due to the development of diverse resistance mechanisms. New therapeutic targets have emerged from studies of the genetic profile of melanocytes and from the identification of molecular factors involved in the pathogenesis of the malignant transformation. In this review, we aim to survey therapies approved and under evaluation for melanoma treatment and relevant research on the molecular mechanisms underlying melanomagenesis.