Implications from proteomic studies investigating circadian rhythm disorder-regulated neurodegenerative disease pathology
Implications from proteomic studies investigating circadian rhythm disorder-regulated neurodegenerative disease pathology
复制标题
蛋白质组学研究对昼夜节律紊乱调节的神经退行性疾病病理学的启示
DOI：
10.1016/j.smrv.2023.101789
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发表时间：
2023-05-28
影响因子：
10.5
通讯作者：
Yu，Yang
中科院分区：
文献类型：
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作者：
Liu，Weiwei;Ma，Ruze;Yu，Yang
神经退行性疾病(NDS)影响着世界上15%的人口，并正在成为全球范围内日益常见的致病和死亡原因。据报道，昼夜节律紊乱(CRD)参与了多种神经系统疾病的病原调控，包括阿尔茨海默病、帕金森病、亨廷顿病、多发性硬化症和肌萎缩侧索硬化症。蛋白质组学技术有助于探索NDS患者CRDS的治疗靶点。在这里，我们回顾了在以前的蛋白质组学研究中发现的关键差异表达(DE)蛋白质，这些蛋白质研究包括NDS、CRD和相关模型，以及通过浓缩分析确定的相关途径。此外，我们总结了上述研究的优点和不足，并提出了新的蛋白质组学技术，以精确研究昼夜节律紊乱介导的ND病理调控。这篇综述为精确研究昼夜节律紊乱介导的ND病理调控提供了理论和技术参考。
Neurodegenerative diseases (NDs) affect 15% of the world's population and are becoming an increasingly common cause of morbidity and mortality worldwide. Circadian rhythm disorders (CRDs) have been reported to be involved in the pathogenic regulation of various neurologic diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis and amyotrophic lateral sclerosis. Proteomic technology is helpful to explore treatment targets for CRDs in patients with NDs. Here, we review the key differentially expressed (DE) proteins identified in previous proteomic studies investigating NDs, CRDs and associated models and the related pathways identified by enrichment analysis. Furthermore, we summarize the advantages and disadvantages of the above studies and propose new proteomic technologies for the precise study of circadian disorder-mediated regulation of ND pathology. This review provides a theoretical and technical reference for the precise study of circadian disorder-mediated regulation of ND pathology.