Contribution of the spinal microglia to bee venom-induced inflammatory pain in conscious rats
Contribution of the spinal microglia to bee venom-induced inflammatory pain in conscious rats
复制标题
脊髓小胶质细胞对蜂毒引起的清醒大鼠炎症性疼痛的作用
DOI：
10.1016/j.neulet.2012.11.028
复制
发表时间：
2013-02-08
影响因子：
2.5
通讯作者：
Lu, Yao
中科院分区：
文献类型：
--
作者：
Chen, Hui-Sheng;Wang, Jian-Xiu;Lu, Yao
众所周知，脊髓胶质细胞在疼痛的发病机制中起着关键作用。本研究旨在探讨脊髓小胶质细胞在蜂毒诱导的持续性自发伤害性感觉(PSN)、机械性痛敏和炎症中的作用。我们测定了小胶质细胞抑制剂米诺环素对BV诱导的PSN、机械性痛敏和炎性肿胀的影响。鞘内注射不同剂量的米诺林可显著抑制BV诱导的PSN和机械性痛觉过敏，但对BV诱导的炎性肿胀无明显影响。这些数据表明，脊髓小胶质细胞的激活可能在BV诱导的伤害性反应中发挥关键作用，而不是炎症。(C)2012爱思唯尔爱尔兰有限公司。保留所有权利。
It is well known that spinal glia plays a key role in the pathogenesis of pain. The present study was designed to determine the roles of spinal microglia in bee venom-induced persistent spontaneous nociception (PSN), mechanical hyperalgesia and inflammation. We determined the effects of microglia inhibitor minocycline on BV-induced PSN, mechanical hyperalgesia and inflammatory swelling. Pre-treatment with intrathecal administration of minocyline at different doses significantly inhibited BV-induced PSN and mechanical hyperalgesia, but had no effect on BV-induced inflammatory swelling. These data suggest that the activation of spinal microglia may play a key role in BV-induced nociception, but not inflammation. (C) 2012 Elsevier Ireland Ltd. All rights reserved.