Correlation between maternal first trimester plasma leptin levels and birth weight among normotensive and preeclamptic women
Correlation between maternal first trimester plasma leptin levels and birth weight among normotensive and preeclamptic women
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DOI：
10.3109/14767051003678283
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发表时间：
2010-12-01
影响因子：
1.8
通讯作者：
Galazios, George
中科院分区：
文献类型：
--
作者：
Papastefanou, Ioannis;Samolis, Sofoklis;Galazios, George
Objective.探讨孕妇孕早期血清瘦素水平与新生儿体重的关系。该研究包括37名先兆子痫妇女和53名血压正常的妇女作为对照组。在妊娠13周时抽取母体血液样品用于测量瘦素浓度。出生体重根据产妇和产科特征转换为z分数，基于定制的百分位数。采用非参数检验、t检验、Pearson相关分析、斯皮尔曼相关分析和线性回归分析。先兆子痫妇女的孕前体重指数和孕早期血浆瘦素水平显著较高（分别为p = 0.015和p < 0.001）。子痫前期组和对照组的出生体重z评分与瘦素水平呈负相关（r =-0.570，p = 0.001）（r =-0.477，p = 0.001）。回归模型显示两组的出生体重z评分与瘦素之间存在显著的负相关。母体妊娠前三个月血清瘦素与子痫前期孕妇新生儿体重呈显著负相关，在血压正常的孕妇中也有较小程度的负相关。一个可能的瘦素参与病理生理适应，定义胎儿生长潜力可以支持。
Objective. To determine the connection between maternal first trimester serum leptin levels and newborn weight.Methods. The study included 37 preeclamptic women and 53 normotensive women who considered the control group. Maternal blood samples were withdrawn at 13 weeks of gestation for the measurement of leptin concentrations. Birth weights were transformed to z-scores according to maternal and obstetrical features, based on customised centiles. Non-parametric tests, student's t-test, Pearson's correlation, Spearman's correlation and linear regression analysis were performed in our analysis.Results. Pre-pregnancy body mass index and first trimester maternal plasma leptin levels were significantly higher among women with preeclampsia (p = 0.015 and p < 0.001, respectively). Birth weight z-score was negatively correlated with leptin levels (r = -0.570, p < 0.001), in preeclamptic group and in control group (r = -0.477, p < 0.001). The regression modelling demonstrated a significant negative association between birth weight z-scores and leptin for both groups.Conclusion. Maternal first trimester serum leptin demonstrates a significant negative association with neonatal weight in preeclamptic pregnancies and to a lesser extent in normotensive pregnancies. A possible leptin's involvement in pathophysiological adaptations that define the foetal growth potential can be supported.