Total Brain Volumetric Measures and Schizophrenia Risk: A Two-Sample Mendelian Randomization Study.
Total Brain Volumetric Measures and Schizophrenia Risk: A Two-Sample Mendelian Randomization Study.
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总脑容量测量和精神分裂症风险：两样本孟德尔随机研究
DOI：
10.3389/fgene.2022.782476
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发表时间：
2022
影响因子：
3.7
通讯作者：
Liu, Feng
中科院分区：
文献类型：
--
作者：
Zhu, Dan;Wang, Chunyang;Guo, Lining;Si, Daojun;Liu, Mengge;Cai, Mengjing;Ma, Lin;Fu, Dianxun;Fu, Jilian;Wang, Junping;Liu, Feng
Schizophrenia (SCZ) is an idiopathic psychiatric disorder with a heritable component and a substantial public health impact. Although abnormalities in total brain volumetric measures (TBVMs) have been found in patients with SCZ, it is still unknown whether these abnormalities have a causal effect on the risk of SCZ. Here, we performed a Mendelian randomization (MR) study to investigate the possible causal associations between each TBVM and SCZ risk. Specifically, genome-wide association study (GWAS) summary statistics of total gray matter volume, total white matter volume, total cerebrospinal fluid volume, and total brain volume were obtained from the United Kingdom Biobank database (33,224 individuals), and SCZ GWAS summary statistics were provided by the Psychiatric Genomics Consortium (150,064 individuals). The main MR analysis was conducted using the inverse variance weighted method, and other MR methods, including MR-Egger, weighted median, simple mode, and weighted mode methods, were performed to assess the robustness of our findings. For pleiotropy analysis, we employed three approaches: MR-Egger intercept, MR-PRESSO, and heterogeneity tests. No TBVM was causally associated with SCZ risk according to the MR results, and no significant pleiotropy or heterogeneity was found for instrumental variables. Taken together, this study suggested that alterations in TBVMs were not causally associated with the risk of SCZ.
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影响因子：
7.7
作者：
Bowden J;Del Greco M F;Minelli C;Davey Smith G;Sheehan NA;Thompson JR
通讯作者：
Thompson JR
影响因子：
64.8
作者：
Elliott LT;Sharp K;Alfaro-Almagro F;Shi S;Miller KL;Douaud G;Marchini J;Smith SM
通讯作者：
Smith SM
DOI：
10.1097/ede.0000000000000559
发表时间：
2017-01
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Burgess S;Bowden J;Fall T;Ingelsson E;Thompson SG
通讯作者：
Thompson SG
影响因子：
4.5
作者：
Kempton, Matthew J.;Stahl, Daniel;DeLisi, Lynn E.
通讯作者：
DeLisi, Lynn E.
影响因子：
81.5
作者：
Kahn, Rene S.;Sommer, Iris E.;Insel, Thomas R.
通讯作者：
Insel, Thomas R.