Associations between prenatal exposure to organochlorine pesticides and thyroid hormone levels in mothers and infants: The Hokkaido study on environment and children's health
Associations between prenatal exposure to organochlorine pesticides and thyroid hormone levels in mothers and infants: The Hokkaido study on environment and children's health
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产前接触有机氯农药与母婴甲状腺激素水平之间的关联：北海道环境与儿童健康研究
DOI：
10.1016/j.envres.2020.109840
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发表时间：
2020
影响因子：
8.3
通讯作者：
Kishi Reiko
中科院分区：
文献类型：
--
作者：
Yamazaki Keiko;Itoh Sachiko;Araki Atsuko;Miyashita Chihiro;Minatoya Machiko;Ikeno Tamiko;Kato Shizue;Fujikura Kaori;Mizutani Futoshi;Chisaki Yoichi;Kishi Reiko
有机氯农药是一种对神经发育有潜在不良影响的环境污染物。先前关于产前暴露于OCPs与母亲或婴儿甲状腺激素系统之间关系的研究结果不一致。此外，暴露于多种ocp和其他化合物的影响尚不清楚。因此，我们的研究旨在检查OCP暴露与母亲和婴儿甲状腺激素系统之间的关系。我们还利用加权分位数和（WQS）方法探讨了OCPs的多重暴露效应以及每种化合物的影响。研究人群包括北海道研究的514名参与者，从2002年到2005年在日本札幌的一家医院招募。为了对29种OCPs进行量化，采用气相色谱/质谱法对母体血液样本进行分析。用于测量促甲状腺激素（TSH）和游离甲状腺素（FT4）水平的血液样本来自妊娠早期（平均11.4周）的母亲，以及7至43日龄的婴儿。333对母子的OCP和甲状腺激素测量数据被纳入最终分析。多变量回归模型显示母体FT4与o，p ' -二氯二苯二氯乙烯（DDE），o,p ' -二氯二苯三氯乙烷（DDT）和狄氏剂水平呈负相关。WQS分析显示，对滴滴涕（48.6%）、顺式七氯环氧乙烷（22.8%）、狄氏剂（15.4%）是造成OCPs对母体FT4多重暴露效应的主要因素。对于婴儿，我们发现FT4与顺-非草胺和灭螨之间存在正相关。多重暴露效应中贡献最大的化合物是反式非草胺（27.1%）和顺式非草胺（13.8%），而一些化合物通过小质量贡献WQS（0.4-9.1%）。这些结果表明，OCPs，即使在非常低的水平，可能会影响母亲和儿童的甲状腺激素水平，这可能会调节儿童发育。
Organochlorine pesticides (OCPs) are environmental contaminants with potentially adverse effects on neurodevelopment. Previous findings on the association between prenatal exposure to OCPs and the maternal or infant thyroid hormone system are inconsistent. Moreover, the influence of exposure to multiple OCPs and other chemical compounds is not clearly understood. Our study therefore aimed to examine the association between OCP exposure and both maternal and infant thyroid hormone systems. We also explored multiple exposure effects of OCPs and the influence of each compound using weighted quantile sum (WQS) methods. The study population included 514 participants in the Hokkaido study, recruited from 2002 to 2005 at one hospital in Sapporo, Japan. To quantify 29 OCPs, maternal blood samples were analyzed using gas chromatography/mass spectrometry. Blood samples for measuring thyroid stimulating hormone (TSH) and free thyroxine (FT4) levels were obtained from mothers during the early gestational stage (mean 11.4 weeks), and from infants between 7 and 43 days of age. The data of 333 mother child pairs with OCP and thyroid hormone measurements were included in the final analyses. Multivariate regression models showed a negative association between maternal FT4 and levels ofo,p’-dichlorodiphenyldichloroethylene (DDE),o,p’-dichlorodiphenyltrichloroethane (DDT), and dieldrin. The WQS analysis showed thato,p’-DDT (48.6%),cis-heptachlorepoxide (22.8%), dieldrin (15.4%) were the primary contributors to the significant multiple exposure effect of OCPs on maternal FT4. For infants, we found a positive association between FT4 andcis-nonachlor and mirex. The most contributory compounds in the multiple exposure effect weretrans-nonachlor (27.1%) andcis-nonachlor (13.8%), while several compounds contributed to the WQS via small weights (0.4–9.1%). These results indicate that OCPs, even at very low levels, may influence maternal and child thyroid hormone levels, which could modulate child development.