Proposal for the Nomenclature of Human Plasminogen (PLG) Polymorphism
Proposal for the Nomenclature of Human Plasminogen (PLG) Polymorphism
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人纤溶酶原 (PLG) 多态性命名的提案
DOI：
10.1111/j.1423-0410.1986.tb01963.x
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发表时间：
1986
期刊：
影响因子：
2.7
通讯作者：
S. Weidinger
中科院分区：
文献类型：
--
作者：
U. Skoda;J. Bertrams;D. Dykes;H. Eiberg;M. Hobart;K. Hummel;P. Kühnl;G. Mauff;S. Nakamura;H. Nishimukai;D. Raum;K. Tokunaga;S. Weidinger
抽象。人纤溶酶原（PLG）多态性自发现以来，在群体遗传学和法医血液学中得到了广泛的认可。由于大量的变异等位基因的描述，PLG参考分型和纤溶酶原专题讨论会举行，在命名建议开幕。比较PLG变体的技术基于等电聚焦和随后通过酪蛋白溶解覆盖和“蛋白质”印迹的检测。分型结果允许比较迄今为止描述的变体名称，并导致PLG多态性的新命名建议。建议将在所有研究的人种中发现的两种最常见的等位基因称为：PLG*A（以前也称为PLG*1）和PLG*B（以前也称为PLG*2），已知的酸性pI变体：PLG*A1至 *A3，中间变体：PLG*M1至 *M5，PLG*M5无功能活性，碱性变体：PLG*B1至 *B3。对于新发现的变异的未来分类，应在参与参考分型的任何实验室比较样本。
Abstract. Since its discovery, human plasminogen (PLG) polymorphism has received widespread acceptance in population genetics and forensic haematology. Due to the large number of variant alleles described, a PLG reference typing and Plasminogen Symposium was held, at which a nomenclature proposal was inaugurated. The technology of comparing PLG variants was based on isoelectric focusing and subsequent detection by caseinolytic overlay and ‘Western’ blotting. Typing results permitted comparison of so far described variant designations and resulted in a new nomenclature proposal for PLG polymorphism. It is recommended that the two most common alleles found in all investigated races be called: PLG*A (previously also PLG*1) and PLG*B (previously also PLG*2), the known variants with acidic pI: PLG*A1 to *A3, intermediate variants: PLG*M1 to *M5, PLG*M5 being functionally inactive, and basic variants: PLG*B1 to *B3. For future classification of newly discovered variants, samples should be compared at any of the laboratories participating in the reference typing.