DOES GUAR GUM IMPROVE POST-PRANDIAL HYPERGLYCEMIA IN HUMANS BY REDUCING SMALL INTESTINAL CONTACT AREA
DOES GUAR GUM IMPROVE POST-PRANDIAL HYPERGLYCEMIA IN HUMANS BY REDUCING SMALL INTESTINAL CONTACT AREA
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DOI：
10.1079/bjn19840088
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发表时间：
1984-01-01
影响因子：
3.6
通讯作者：
READ, NW
中科院分区：
文献类型：
--
作者：
BLACKBURN, NA;HOLGATE, AM;READ, NW
The possibility that viscous polysaccharides, such as guar gum, could lower post-prandial blood glucose levels in part by restricting carbohydrate solutions to a smaller area of small intestine was investigated in 20 healthy human volunteers. Addition of guar gum (22 .cntdot. 5 g/l) delayed the mouth-to-cecum transit time of a hypotonic lactulose drink, but did not affect gastric emptying. When a 250 ml solution containing 50 g glucose was confined to a 550 mm length of intestine by an occluding balloon attached to an intestinal tube, maximum blood glucose response was significantly reduced (P < 0.05) though only by 0.9 mmol/l. Addition of guar gum (36 g/l) had no effect on the distribution of a radio-labeled glucose drink (250 ml; 200 g glucose/l) in the small intestine, monitored using a gamma camera, although it significantly delayed gastric emptying (t1/2 (min): guar gum vs. control 115 (SE 15) vs. 73 (SE 8)). Reduced contact area is unlikely to be one of the mechanisms by which guar gum improves glucose tolerance.
