Preimplantation genetic diagnosis (PGD) improves pregnancy outcome for translocation carriers with a history of recurrent losses
Preimplantation genetic diagnosis (PGD) improves pregnancy outcome for translocation carriers with a history of recurrent losses
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DOI：
10.1016/j.fertnstert.2009.02.060
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发表时间：
2010-06-01
影响因子：
6.7
通讯作者：
Munne, Santiago
中科院分区：
文献类型：
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作者：
Fischer, Jill;Colls, Pere;Munne, Santiago
目的：探讨有3次或3次以上妊娠损失的易位携带者进行植入前遗传学诊断是否能降低失败率。设计：数据回顾。地点：为体外受精组服务的植入前遗传学诊断实验室。患者(S)：192例因相互易位或罗伯逊易位而接受植入遗传学诊断的患者，既往有3次或3次以上妊娠损失。干预(S)：易位的植入前遗传学诊断。主要预后指标(S)：妊娠丢失率，妊娠成功率定义为妊娠晚期至少分娩一个孩子或持续妊娠，结果(S)：妊娠期妊娠丢失率从既往非妊娠期妊娠的88.5%和自然妊娠的35%降至13%。妊娠成功率为87%。受孕发生在平均1.4个周期或
Objective: To determine if preimplantation genetic diagnosis (PGD) for translocation carriers with three or more pregnancy losses reduces loss rates.Design: Retrospective review of data.Setting: Preimplantation genetic diagnosis laboratory servicing IVF groups.Patient(s): Patients (n = 192) undergoing PGD for either a reciprocal translocation or Robertsonian translocation who had three or more previous pregnancy losses.Intervention(s): Preimplantation genetic diagnosis for translocations.Main Outcome Measure(s): Pregnancy loss rate, pregnancy success rate defined as delivery of at least one child or an ongoing pregnancy in the third trimester, and length of time to success.Result(s): Pregnancy loss rate was significantly reduced to 13% post-PGD compared with 88.5% in previous non-PGD pregnancies and to 35% to 64% from naturally conceived pregnancies as reported in the literature. Pregnancy success rate was 87%. Conception occurred after an average of 1.4 cycles or