The spectrum of immunologic abnormalities and clinical findings in homosexually active men.
The spectrum of immunologic abnormalities and clinical findings in homosexually active men.
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同性恋活跃男性的免疫异常谱和临床表现。
DOI：
10.1093/infdis/149.2.148
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Phair,JP
中科院分区：
文献类型：
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作者：
Kalish,SB;Ostrow,DG;Goldsmith,J;Hsu,CC;Chmiel,JS;Wallemark,CB;Phair,JP
对181名男性进行了临床和实验室评估；研究人群包括131名同性恋或双性恋男性(根据症状和体检异常结果被分成三组之一)、39名异性恋男性(作为对照)和11名获得性免疫缺陷综合征(AIDS)男性。男同性恋者出现特殊症状和/或淋巴结病与免疫调节紊乱有关。无症状、同性恋活跃的男性中有很大比例的淋巴细胞数量、亚群和亚类出现异常。有症状的患者具有与艾滋病患者相似的临床表现、免疫学改变和造血异常。这些数据表明，临床评估与实验室研究相结合，可能有助于识别罹患艾滋病风险增加的个体。
Clinical and laboratory evaluations of 181 men were performed; the population studied included 131 homosexual or bisexual men (who were stratified into one of three groups on the basis of symptomatology and abnormal findings on physical examination), 39 heterosexual men (who served as controls), and 11 men with acquired immunodeficiency syndrome (AIDS). The presence of specific symptoms and/or lymphadenopathy in homosexual men was associated with perturbation of immunoregulation. A large percentage of asymptomatic, homosexually active men had abnormalities in lymphocyte numbers, subpopulations, and subclasses. Symptomatic individuals had clinical findings, immunologic alterations, and abnormalities of hematopoiesis similar to those found in patients with AIDS. These data suggest that clinical evaluation in conjunction with laboratory studies may serve to identify individuals at increased risk of developing AIDS.