A Prospective Study of Serum 25-Hydroxyvitamin D Levels, Blood Pressure, and Incident Hypertension in Postmenopausal Women
A Prospective Study of Serum 25-Hydroxyvitamin D Levels, Blood Pressure, and Incident Hypertension in Postmenopausal Women
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DOI：
10.1093/aje/kwr274
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发表时间：
2012-01-01
影响因子：
5
通讯作者：
Manson, JoAnn E.
中科院分区：
文献类型：
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作者：
Margolis, Karen L.;Martin, Lisa W.;Manson, JoAnn E.
在随机试验中，补充维生素D对血压的影响一直是模棱两可的，而大多数前瞻性队列研究表明，25-羟基维生素D(25(OH)D)水平较高的人患高血压的风险较低。作者研究了1993年至1998年间4863名参加妇女健康倡议的绝经后妇女的25(OH)D水平与血压变化和高血压事件之间的关系。在7年中，25(OH)D的四分位数调整后的平均收缩压或舒张压变化没有显著差异。与最低的四分位数相比，25(OH)D的上三个四分位数发生高血压的协变量调整风险略低，但这只在第三个四分位数有统计学意义(危险比=0.67，95%可信区间：0.46，0.96)。未经变换或经对数变换的25(OH)D连续值对高血压发病风险无显著的线性或非线性趋势。在本研究中，绝经后妇女血清25(OH)D水平与血压变化无关，且与较低高血压发病风险相关的证据薄弱。
In randomized trials, the effect of vitamin D supplementation on blood pressure has been equivocal, while most prospective cohort studies have shown that the risk of incident hypertension is lower in people with higher levels of 25-hydroxyvitamin D (25(OH)D). The authors examined the association between levels of 25(OH)D and changes in blood pressure and incident hypertension in 4,863 postmenopausal women recruited into the Women's Health Initiative between 1993 and 1998. Over 7 years, there were no significant differences in the adjusted mean change in systolic or diastolic blood pressure by quartile of 25(OH)D. The covariate-adjusted risk of incident hypertension was slightly lower in the upper 3 quartiles of 25(OH) D compared with the lowest quartile, but this was statistically significant only in the third quartile (hazard ratio = 0.67, 95% confidence interval: 0.46, 0.96). There was no significant linear or nonlinear trend in the risk of incident hypertension by untransformed or log-transformed continuous values of 25(OH)D. In postmenopausal women in this study, serum levels of 25(OH)D were not related to changes in blood pressure, and evidence for an association with lower risk of incident hypertension was weak.