"Stemness": Transcriptional profiling of embryonic and adult stem cells
"Stemness": Transcriptional profiling of embryonic and adult stem cells
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DOI：
10.1126/science.1072530
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发表时间：
2002-10-18
期刊：
影响因子：
56.9
通讯作者：
Melton, DA
中科院分区：
文献类型：
--
作者：
Ramalho-Santos, M;Yoon, S;Melton, DA
将小鼠胚胎干细胞、神经干细胞和造血干细胞的转录图谱进行比较，以确定干细胞的基因程序。共有216个基因在这三种类型的干细胞中均富集，其中一些基因在基因组中呈簇状分布。与分化细胞类型相比，干细胞表达功能未知的基因（以表达序列标签表示）数量明显更多。胚胎干细胞和神经干细胞在转录水平上有许多相似之处。这些结果为更详细地理解干细胞生物学提供了基础。
The transcriptional profiles of mouse embryonic, neural, and hematopoietic stem cells were compared to de ne a genetic program for stem cells. A total of 216 genes are enriched in all three types of stem cells, and several of these genes are clustered in the genome. When compared to differentiated cell types, stem cells express a significantly higher number of genes ( represented by expressed sequence tags) whose functions are unknown. Embryonic and neural stem cells have many similarities at the transcriptional level. These results provide a foundation for a more detailed understanding of stem cell biology.