Dibromoisobenzofuran as a Formal Equivalent of Didehydroisobenzofuran: Reactive Platform for Expeditious Assembly of Polycycles
Dibromoisobenzofuran as a Formal Equivalent of Didehydroisobenzofuran: Reactive Platform for Expeditious Assembly of Polycycles
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DOI：
10.1021/ol4032792
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发表时间：
2014-01-03
期刊：
影响因子：
5.2
通讯作者：
Hamura, Toshiyuki
中科院分区：
文献类型：
--
作者：
Haneda, Hiroshi;Eda, Shohei;Hamura, Toshiyuki
研究了二脱氢异苯并呋喃的一种形式等价物二溴异苯并呋喃的双向成环反应。重要的是，选择性溴锂交换允许与两种不同的亲芳体串联生成苄炔和双环加成。还描述了其在合成取代并五苯中的应用。
Two-directional annulation of dibromoisobenzofuran, a formal equivalent to didehydroisobenzofuran, was developed. Importantly, selective bromine lithium exchange allows the tandem generation of benzynes and dual cycloadditions with two different arynophiles. Also described is the application to the synthesis of a substituted pentacene.