Are adhesion molecules involved in stress-induced changes in lymphocyte distribution?
Are adhesion molecules involved in stress-induced changes in lymphocyte distribution?
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DOI：
10.1016/s0024-3205(01)01200-0
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发表时间：
2001-07-27
期刊：
影响因子：
6.1
通讯作者：
Shanks, N
中科院分区：
文献类型：
--
作者：
Bauer, ME;Perks, P;Shanks, N
急性心理应激与循环细胞群的重要变化和细胞介导的免疫反应的减少有关。然而，人们对这些现象背后的机制知之甚少。在这项研究中，我们研究了(i) Sprague-Dawley大鼠急性和慢性约束应激对外周血淋巴细胞亚群的影响，（ii）粘附分子（β 2整合素）的表达，（iii）还确定了糖皮质激素是否可能导致应激相关的细胞再分配变化。我们观察到淋巴细胞分布的时间依赖性变化，包括急性短暂抑制后外周T辅助细胞百分比下降（-21%）和NK细胞数量增加（88%）。急性应激还发现，T细胞上β -整合素（cdi1a和CD11b）的表达总体上调，血浆皮质酮水平升高（1049%）。然而，在先前暴露于慢性约束应激的动物中，这种应激反应被发现是习惯性的（-75% vs.急性）。在先前暴露于慢性间歇性约束应激的动物或再次暴露于相同应激源的慢性应激动物中，未观察到应激对循环淋巴细胞的影响。我们的研究结果表明，1)应激改变了淋巴细胞的分布，2)粘附分子可能参与应激诱导的t细胞分布的改变，3)这些变化可能与循环糖皮质激素有关，并受到反复应激暴露的适应。(C) 2001爱思唯尔科学公司版权所有。
Acute psychological stress is associated with important changes in circulating cell populations and reductions in cell-mediated immune responses. However, the mechanisms underlying these phenomena are poorly understood. In this study, we investigated (i) acute and chronic restraint stress effects in Sprague-Dawley rats on peripheral lymphocyte subsets and (ii) adhesion molecule (beta2 integrins) expression and (iii) also determined whether glucocorticoids could underlie stress-related changes in cellular redistribution. We observed time-dependent changes in lymphocyte distribution including decreased (-21%) percentages of peripheral T helper cells and increased (88%) NK cell numbers following acute brief restraint. Acute stress was also found to overall upregulate beta2-integrin (CD I I a and CD11b) expression on T cells and to raise (1049%) plasma corticosterone levels. However, this stress response was found habituated (-75% vs. acute) in the animals previously exposed to chronic restraint stress. Stress effects on circulating lymphocytes were not observed in animals previously exposed to chronic intermittent restraint stress or chronically stressed animals re-exposed to the same stressor. Our results indicate that 1) stress alters lymphocyte distribution, 2) that adhesion molecules may be involved in stress-induced alterations of T-cell distribution and 3) that these changes may be related to circulating glucocorticoids and subjected to adaptation with repeated stress exposure. (C) 2001 Elsevier Science Inc. All rights reserved.