Effects of Mother's Dietary Exposure to Acesulfame-K in Pregnancy or Lactation on the Adult Offspring's Sweet Preference
Effects of Mother's Dietary Exposure to Acesulfame-K in Pregnancy or Lactation on the Adult Offspring's Sweet Preference
复制标题
DOI：
10.1093/chemse/bjr050
复制
发表时间：
2011-11-01
期刊：
影响因子：
3.5
通讯作者：
Deng, Shao-Ping
中科院分区：
文献类型：
--
作者：
Zhang, Gen-Hua;Chen, Meng-Ling;Deng, Shao-Ping
本研究探讨母亲在怀孕或哺乳期间接触人工甜味剂安赛蜜（AK）是否会影响其成年后代的甜味偏好。结果发现，母亲的饮食暴露于AK在怀孕或哺乳期降低了AK和蔗糖溶液的偏好阈值在成年后代，而偏好模式和最喜爱的浓度为AK或蔗糖溶液没有改变。此外，与对照组相比，在一定浓度范围内的AK或蔗糖溶液暴露组的偏好评分显着增加。本文用反相高效液相色谱-质谱联用技术研究了单次口服AK溶液后，孕妇羊水和哺乳期母乳中AK的存在及其24 h内的动态变化。我们的数据表明，AK可以通过母亲的羊水或母乳被出生前或出生后的小鼠摄入，对成年小鼠的甜味偏好产生长期的作用。
This study investigates whether mother's exposure to the artificial sweetener acesulfame-K (AK) during pregnancy or lactation affected her adult offspring's sweet preference. It was found that mother's dietary exposure to AK in pregnancy or lactation decreased the preference thresholds for AK and sucrose solutions in the adult offspring, whereas the preference pattern and the most preferred concentration for AK or sucrose solution were unchanged. Furthermore, the preference scores in the exposure groups were increased significantly when compared with the control group at a range of concentrations for AK or sucrose solution. The existence of AK and its dynamic changes within 24 h in amniotic fluid during pregnancy or in mother's milk during lactation after a single oral infusion of AK solution were revealed by the methods of reversed-phase high-performance liquid chromatography and mass spectrometry. Our data suggest that AK can be ingested by the prenatal or postnatal mice through their mother's amniotic fluid or breast milk, producing a long-dated function on the adult's sweet preference.