Spot urinary sodium in acute decompensation of advanced heart failure and dilutional hyponatremia: insights from DRAIN trial
Spot urinary sodium in acute decompensation of advanced heart failure and dilutional hyponatremia: insights from DRAIN trial
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DOI：
10.1007/s00392-020-01617-w
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发表时间：
2020-03-06
影响因子：
5
通讯作者：
De Ferrari, Gaetano Maria
中科院分区：
文献类型：
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作者：
Galluzzo, Alessandro;Frea, Simone;De Ferrari, Gaetano Maria
利尿剂抵抗预示着急性心力衰竭预后不良，尤其是在晚期。早期发现对利尿剂的不良反应可能有助于改善治疗和预后。在开始静脉注射呋塞米后2小时出现的点状尿钠排泄（UNa+）被认为是利尿反应的早期指标。本研究旨在确定早期尿钠排泄在晚期慢性心力衰竭（ACHF）和利尿剂抵抗高危患者住院治疗中的作用。方法和结果我们对DRAIN试验进行了亚组分析，DRAIN试验是一项随机临床试验，对80例急性失代偿的ACHF患者（NYHA IV级，EF
Background Diuretic resistance portends a poor prognosis in acute heart failure, especially in advanced stages. Early identification of a poor response to diuretics may help to improve treatment and outcomes. Spot natriuresis (UNa+) at 2 h from the start of intravenous furosemide has been proposed as an early indicator of diuretic response. Our paper aimed to determine the role of early natriuresis in patients hospitalized with advanced chronic heart failure (ACHF) and high risk of diuretic resistance. Methods and results We performed a sub-analysis of the DRAIN trial, a randomized clinical trial on 80 patients with acute decompensation of ACHF (NYHA IV,EF