T cell adhesion to endothelium: the FRC conduit system and other anatomic and molecular features which facilitate the adhesion cascade in lymph node.
T cell adhesion to endothelium: the FRC conduit system and other anatomic and molecular features which facilitate the adhesion cascade in lymph node.
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DOI：
10.1006/smim.1993.1031
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发表时间：
1993-08-01
影响因子：
7.8
通讯作者：
Shaw, S
中科院分区：
文献类型：
--
作者：
Anderson, A O;Shaw, S
由于T细胞监视依赖于从血液进入组织并再次返回的运动，因此快速，有效和选择性的T细胞粘附到血管内皮是必不可少的。这种粘附涉及通过最近的共识模型阐明的多步骤级联：（1）通过选择素介导的相互作用的初始拴系;（2）通过内皮表面处或附近的配体触发T细胞整联蛋白的粘附功能;和（3）由T细胞整联蛋白介导的强粘附。我们概括了这个模型，特别是当它涉及淋巴结时，并探索了有助于该部位粘附级联反应有效性的其他分子和解剖学因素：（1）细胞因子/可溶性介质作为触发配体的重要性;（2）高内皮微静脉（HEV）内皮上的糖萼和蛋白聚糖在捕获和呈递触发细胞因子中的作用;（3）我们所称的“成纤维网状细胞（FRC）导管系统”在将细胞因子快速转运到HEV中的显著功能;（4）HEV内皮之间的瓣阀连接的独特解剖结构在使细胞因子内渗和淋巴细胞迁移中的重要性。总之，这些分子机制和淋巴结的这三个解剖特征促进了淋巴细胞极其有效地运输到该部位，这对T细胞介导的免疫应答至关重要。类似的机制有助于T细胞与其他部位的内皮细胞相互作用。
Since T cell surveillance depends on movement from blood into tissue and back again, rapid, efficient and selective T cell adhesion to vascular endothelium is essential. This adhesion involves a multistep cascade clarified by a recent consensus model: (1) initial tethering by selectin-mediated interactions; (2) triggering of adhesive function of T cell integrins by ligands at or near the endothelial surface; and (3) strong adhesion mediated by T cell integrins. We recapitulate this model, particularly as it pertains to the lymph node, and explore additional molecular and anatomic elements which contribute to the effectiveness of the adhesion cascades at that site: (1) importance of cytokines/soluble mediators as triggering ligands; (2) role of glycocalyx and proteoglycans on high endothelial venule (HEV) endothelium in capturing and presenting triggering cytokines; (3) remarkable function of what we designate the 'fibroblastic reticular cell (FRC) conduit system' in rapidly transporting cytokines to the HEV; (4) importance of the unique anatomy of the flap-valve junctions between HEV endothelium in enabling intravasation of cytokines and transmigration of lymphocytes. Taken together, these molecular mechanisms and these three anatomic features of lymph node facilitate extremely efficient lymphocyte traffic to this site critical for T cell-mediated immune responses. Analogous mechanisms contribute to T cell interaction with endothelium at other sites.