Progression of renal fibrosis: the underestimated role of endothelial alterations.
Progression of renal fibrosis: the underestimated role of endothelial alterations.
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DOI：
10.1186/1755-1536-5-s1-s15
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Chatziantoniou C
中科院分区：
文献类型：
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作者：
Guerrot D;Dussaule JC;Kavvadas P;Boffa JJ;Chadjichristos CE;Chatziantoniou C
肾脏的血管是一个异质结构，其功能的完整性是必不可少的调节肾功能。由于内皮在血管生物学中的重要性，因此慢性内皮改变容易损害肾脏生理的多个方面，进而导致肾纤维化。尽管全身内皮功能障碍无疑与慢性肾脏疾病有关，但肾内皮在肾纤维化的发生和发展中的作用在很大程度上仍然难以捉摸。在这篇文章中，我们批判性地回顾了最近支持肾内皮改变对肾脏纤维化的直接和间接贡献的证据。具体来说，本文综述了肾内皮功能障碍和内皮缺乏在实质缺氧、局部炎症调节和肾间充质细胞生成中的潜在意义。此后，我们讨论了在肾纤维化发生的开始和进展过程中针对肾内皮改变的治疗前景。
The vasculature of the kidney is a heterogeneous structure, whose functional integrity is essential for the regulation of renal function. Owing to the importance of the endothelium in vascular biology, chronic endothelial alterations are therefore susceptible to impair multiple aspects of renal physiology and, in turn, to contribute to renal fibrosis. Although systemic endothelial dysfunction is undoubtedly associated with chronic kidney disease, the role of the renal endothelium in the initiation and the progression of renal fibrosis remains largely elusive. In this article, we critically review recent evidence supporting direct and indirect contributions of renal endothelial alterations to fibrosis in the kidney. Specifically, the potential implications of renal endothelial dysfunction and endothelial paucity in parenchymal hypoxia, in the regulation of local inflammation, and in the generation of renal mesenchymal cells are reviewed. We thereafter discuss therapeutic perspectives targeting renal endothelial alterations during the initiation and the progression of renal fibrogenesis.