Loss of functional hemispheric asymmetry in Alzheimer's dementia assessed with near-infrared spectroscopy
Loss of functional hemispheric asymmetry in Alzheimer's dementia assessed with near-infrared spectroscopy
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DOI：
10.1016/s0926-6410(97)00016-5
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发表时间：
1997-07-01
期刊：
影响因子：
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通讯作者：
Strik, WK
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文献类型：
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作者：
Fallgatter, AJ;Roesler, M;Strik, WK
本文应用近红外光谱法（NIRS）对10例阿尔茨海默型痴呆（DAT）患者和10例健康对照者进行了言语流畅性测试（VFT），观察了其左右半球前额叶脑组织中氧合血红蛋白（O_2 HB）和脱氧血红蛋白（HHB）浓度的变化。在神经心理学水平上，健康受试者表现更好的VFT比DAT患者。统计分析的相对浓度的O，HB和HHB测量与近红外光谱在性能的VFT显示一个显着的相互作用的半球的影响与诊断。这一发现的一个可能的解释是，在VFT中的良好表现依赖于在对照组中观察到的主要左半球激活，而在DAT患者中，正确反应的数量较少与这种不对称激活的丧失相关。尽管患者和对照组在VFT的类别版本中表现更好，该任务的代谢影响明显不如字母版本中的显著。这表明，根据对记忆存储的访问类型，不同的能量需求可能被解释为对分类存储信息的能量需求较少的结果，并为人类记忆部门根据分类原则组织的观点提供了进一步的证据。
In a total of 10 patients with dementia of the Alzheimer-type (DAT) and in 10 healthy controls near-infrared spectroscopy (NIRS), a new non-invasive optical method, was used to measure the changes of concentrations of oxy-(O2HB) and deoxyhemoglobin (HHB) in left and right hemispheric prefrontal brain tissue areas during performance of the Verbal Fluency Test (VFT). On a neuropsychological level, the healthy subjects performed better in the VFT than patients with DAT. Statistical analysis of the relative concentrations of O,HB and HHB measured with NIRS during performance of the VFT revealed a significant interaction of the hemispheric effects with the diagnosis. A possible interpretation of this finding is that a good performance in the VFT relies on a predominantly left hemispheric activation observed in controls, whereas a low number of correct responses is associated with a loss of this asymmetric activation in patients with DAT. Although both, patients and controls, performed better in the category version of the VFT, the metabolic effects of this task were significantly less pronounced than in the letter version. This indicates that different energy demands, according to the type of access to the memory stores, may be interpreted as the result of a less energy-demanding access to categorically stored information and adds further evidence to the view that memory departments in humans are organized according to categorical principles.