Cellular Ageing and the Actin Cytoskeleton
Cellular Ageing and the Actin Cytoskeleton
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DOI：
10.1007/978-94-007-2561-4_15
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发表时间：
2012-01-01
期刊：
影响因子：
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通讯作者：
Gourlay, Campbell W.
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文献类型：
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作者：
Amberg, David;Leadsham, Jane E.;Gourlay, Campbell W.
一段时间以来，认为肌动蛋白细胞骨架主要作为支架，在信号级联反应中组装，作为通路的终点，已经占了上风。然而，现在清楚的是，细胞骨架的动态性质与进一步调节细胞活性的下游信号事件有关，并且可以决定细胞命运。这方面的例子包括程序性细胞死亡的调节、体内平衡的维持和细胞衰老的过程。在酵母中，肌动蛋白细胞骨架已被证明与已知在衰老和细胞死亡调节中重要的信号通路直接相互作用。例如，已经发现在氧化应激条件下肌动蛋白细胞骨架所持续的损伤水平与细胞凋亡直接相关。进一步的证据来自于发现基于肌动蛋白的推进机制是线粒体和抗衰老因子遗传到新形成的细胞中所必需的。除此之外，已知肌动蛋白直接影响蛋白质聚集体的形成。在本章中，我们将讨论这些观点，并假设它们对维持细胞内稳态的重要性。
For some time the view that the actin cytoskeleton acts primarily as a scaffold, to be assembled in response to a signaling cascade as an end point in the pathway, has prevailed. However, it is now clear that the dynamic nature of the cytoskeleton is linked to downstream signaling events that further modulate cellular activity, and which can determine cell fate. Examples of this lie within the regulation of programmed cell death, the maintenance of homeostasis and the process of cellular ageing. In yeast the actin cytoskeleton has been shown to interact directly with signaling pathways known to be important in the regulation of both ageing and cell death. For example it has been discovered that the level of damage sustained by the actin cytoskeleton under conditions of oxidative stress is directly linked to apoptosis. Further evidence comes from the finding that actin based propulsion mechanisms are required for the inheritance of mitochondria and anti-ageing factors into newly formed cells. In addition to this actin is known to directly influence the formation of protein aggregations. In this chapter we will discuss these points and postulate as to their significance with respect to the maintenance of cellular homeostasis.