Pulmonary disease due to Mycobacterium intracellulare.
Pulmonary disease due to Mycobacterium intracellulare.
复制标题
细胞内分枝杆菌引起的肺部疾病。
DOI：
10.1164/arrd.1973.108.3.547
复制
发表时间：
1973
期刊：
影响因子：
--
通讯作者：
Raleigh Jw
中科院分区：
文献类型：
--
作者：
H. Yeager;Raleigh Jw
本文回顾了1956 ~ 1971年某医院45例胞内分枝杆菌肺部感染的临床特点、病程和长期随访。50%的患者在2年时仍存活，疾病处于非活动期或静止期，5%的患者在5年时仍存活，46%的患者在5年时仍存活。经过5年的治疗和观察，累积复发率为19.6%。在5年时，20%的患者死于活动性疾病，17%死于非活动性疾病的其他原因。手术治疗的患者明显好于未手术治疗的患者。这项研究再次强调了胞内分枝杆菌引起的肺部感染的严重性。一旦确定患者患有由该微生物引起的进行性实质疾病，联合积极的药物治疗（4至6种药物）和手术切除（如可能）似乎是首选治疗。
The clinical features, course, and long-term follow-up in 45 patients withMycobacterium intracellularepulmonary infection seen at one hospital from 1956 through 1971 were reviewed. Fifty per cent of the patients were alive with inactive or quiescent disease at 2 years, and 46 per cent, at 5 years. The cumulative rate of relapse was 19.6 per cent after 5 years of treatment and observation. At 5 years, 20 per cent of the patients had died with active disease and 17 per cent had died of other causes with inactive disease. Patients who were treated surgically fared significantly better than those who were not.This study re-emphasizes the serious nature of pulmonary infections due toMycobacterium intracellulare. Once it is determined that a patient has progressive parenchymal disease caused by this organism, combined aggressive medical therapy (4 to 6 drugs) and surgical resection, when possible, would seem to be the therapy of choice.