Introduction of ligated vessels promote the retention and regeneration of free fat: constructing a fat flap in tissue engineering chamber
Introduction of ligated vessels promote the retention and regeneration of free fat: constructing a fat flap in tissue engineering chamber
复制标题
结扎血管的引入促进游离脂肪的保留和再生：在组织工程室中构建脂肪瓣
DOI：
10.1080/21623945.2020.1735025
复制
发表时间：
2020-01-01
期刊：
影响因子：
3.3
通讯作者：
Wang, Biao
中科院分区：
文献类型：
--
作者：
Lei, Chen;Cai, Beichen;Wang, Biao
背景：脂肪移植乳房重建由于血运重建不足，保留率不稳定。组织工程室（TEC）模型通过在组织周围引入结扎血管来促进组织再生。我们采用游离脂肪结扎血管，观察TEC模型中移植脂肪的保留率和血运重建情况。方法：SD大鼠24只，随机分为3组。A组：建立标准TEC模型；B组：将腹壁血管束从脂肪瓣上剥离结扎，将脂肪瓣切成颗粒植入腔内；C组：鼠腔内植入游离脂肪。在第6周，收集室中的样品。结果：A、B组体积明显增大，C组体积减小（P < 0.05）
Background: Breast reconstruction with fat grafting has an unstable retention rate due to insufficient revascularization. Tissue Engineering Chamber (TEC) model can promote tissue regeneration in the chamber by introducing ligated vessels around the tissue. We introduced ligated vessels with free fat graft to investigate the retention rate and revascularization of grafted fat that in TEC model. Methods: SD rats (n=24) was divided into 3 groups randomly. Group A: Standard TEC model was constructed; Group B: the epigastric vessel bundles were dissected from the fat flap and ligated, fat flap was cut into granules and planted into the chamber; Group C: Free fat was planted in the chamber. At week 6, samples in the chamber were harvested. Results: Significant volume increase was observed in group A and B, while the volume decreased in group C (P