Lack of Synergy of Erythromycin Combined with Penicillin or Cefotaxime against Streptococcus pneumoniae In Vitro
Lack of Synergy of Erythromycin Combined with Penicillin or Cefotaxime against Streptococcus pneumoniae In Vitro
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DOI：
10.1128/aac.47.3.1151-1153.2003
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发表时间：
2003-03
影响因子：
4.9
通讯作者：
E. Lin;R. Stanek;M. Mufson
中科院分区：
文献类型：
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作者：
E. Lin;R. Stanek;M. Mufson
摘要我们研究了一种大环内酯类抗生素和β-内酰胺类抗生素对不同耐药谱肺炎链球菌的协同作用。红霉素与青霉素或头孢噻肟联合使用的棋盘格和时间杀菌试验基本上显示出无差异，这表明这些抗生素在体外联合使用时在抗链球菌活性方面基本上是单独作用的。肺炎。
ABSTRACT We investigated a possible synergistic effect of a macrolide and β-lactams against Streptococcus pneumoniae strains with different resistance profiles. Checkerboard and time-kill assays of erythromycin combined with penicillin or cefotaxime essentially showed indifference, suggesting that these antibiotics in combinations in vitro act substantially as individuals in their activity against S. pneumoniae.