The nucleolar cycle in man.
The nucleolar cycle in man.
复制标题
人类的核仁循环。
DOI：
--
复制
发表时间：
1977
影响因子：
4
通讯作者：
M. Anastassova
中科院分区：
文献类型：
--
作者：
M. Anastassova
对人胚胎肾和卵巢进行组织培养。在这两种组织的细胞核中都发现了一到十个核仁。核仁的最大数目与第13、14、15、21和22号染色体的10个核仁组织者的rDNA基因表达有关，这对染色体具有次生缩窄，是人类的卫星染色体。具有10、9和8个核仁的细胞所占的比例很小，这是由于3个同源异核中心的快速结合（可能是D组）。两个卫星（SAT）对可能在有丝分裂后结合。融合过程是动态的，产生一个间期核，这是所有SAT染色体结合的表现。核仁的解离发生在进入前期，这是由于染色体的凝聚和rDNA退回到各自的次级缩窄。结果，核仁数又增加了。描述了一次有丝分裂过程中核仁动力学的模式。
Tissue cultures of human embryonal kidney and ovary were examined. In the nuclei of both tissues, one to ten nucleoli have been found. The maximum number of nucleoli is connected with the gene expression of rDNA of the 10 nucleolus organizers of chromosome pairs Nos. 13, 14, 15, 21 and 22, which have secondary constrictions and are the satellite chromosomes in man. The small percentage of cells with 10, 9 and 8 nucleoli is attributed to the rapid association of 3 of the homologous acrocentrics (perhaps of group D). Two of the satellite (SAT) pairs probably associate later after mitosis. The process of fusion is dynamic, resulting in one interphase nucleous--a manifestation of the association of all SAT chromosomes. Dissociation of the nucleolus occurs upon entering prophase, due to the condensation of the chromosomes and retreat of rDNA to the respective secondary constrictions. As a result, the nucleolar number increases again. The pattern of the nucleolar kinetics within the course of one mitotic division is described.