Genetic association analysis of CNR1 and CNR2 polymorphisms with schizophrenia in a Korean population
Genetic association analysis of CNR1 and CNR2 polymorphisms with schizophrenia in a Korean population
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DOI：
10.1097/ypg.0000000000000047
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发表时间：
2014-10-01
影响因子：
0.9
通讯作者：
Woo, Sung-Il
中科院分区：
文献类型：
--
作者：
Bae, Joon Seol;Kim, Jason Yongha;Woo, Sung-Il
位于6q15和1p36.11，大麻素受体1（CNR1）和大麻素受体2（CNR2）基因被认为是一个位置和功能的候选基因的精神疾病，如精神分裂症的发展，因为CNR1是已知的调节多巴胺信号在海马和大脑皮层。然而，很少有遗传学研究已经进行了调查CNR1和CNR2多态性和精神分裂症的风险之间的关联。在这项研究中，虽然结果表明，CNR1和CNR2变异不太可能影响精神分裂症的易感性在韩国人口，研究结果将提供有意义的信息，为进一步的遗传研究。(C)2014年威科健康垂直酒吧利平科特威廉姆斯&威尔金斯。
Located on 6q15 and 1p36.11, cannabinoid receptor 1 (CNR1) and cannabinoid receptor 2 (CNR2) genes are considered to be a positional and functional candidate gene for the development of mental disorders such as schizophrenia because CNR1 is known as a regulator of dopamine signaling in the hippocampus and the cerebral cortex. However, few genetic studies have been carried out to investigate an association of CNR1 and CNR2 polymorphisms and the risk of schizophrenia. In this study, although the result indicates that CNR1 and CNR2 variations are unlikely to influence schizophrenia susceptibility in a Korean population, the findings would provide meaningful information for further genetic studies. (C) 2014 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.